Search for dissertations about: "γ-aminobutyric acid"

Showing result 1 - 5 of 21 swedish dissertations containing the words γ-aminobutyric acid.

2. 1. Neurotransmitter Imaging of the Human Brain : Detecting γ-Aminobutyric Acid (GABA) Using Magnetic Resonance Spectroscopy

   Author : Sofie Tapper; Peter Lundberg; Anders Tisell; Peter Zsigmond; Richard Edden; Linköpings universitet; []
   Keywords : ;

   Abstract : Introduction: In this thesis, MEGA-edited Magnetic Resonance Spectroscopy (MRS) has been used for the purpose of non-invasive detection of !- aminobutyric acid (GABA) within the brain. GABA is the main inhibitory neurotransmitter in the human central nervous system, and glutamate is the corresponding main excitatory neurotransmitter. READ MORE

4. 2. Effects of antipsychotics on GABA neurons in the basal ganglia of the rat

   Author : Jiang Yu; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; antipsychotics; γ-aminobutyric acid; glutamic acid decarboxylase; basal ganglia; entopeduncular nucleus; vacuous chewing movements; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

   Abstract : Antipsychotics are used in the treatment of psychosis and, based on their propensities to induce extrapyramidal side effects (EPS), are divided into typical (haloperidol) and atypical (clozapine) subtypes. The incidence of EPS, arises from an imbalance in the neurotransmission between two majorGABAergic pathways of the basal ganglia that connect the striatum directly to the entopeduncular nucleus (EP) and the substantia nigra reticulata or indirectly via the globus pallidus and the subthalamic nucleus. READ MORE

5. 3. The γ-aminobutyric acid and proton signaling systems in the zebrafish brain : Characterization and effect of stress

   Author : Arianna Cocco; Svante Winberg; William H. J. Norton; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; g-aminobutyric acid GABA ; GABAA receptors; adult zebrafish; central nervous system; gene expression profiling; extracellular acidification.; Biokemi; Biochemistry;

   Abstract : The central nervous system of vertebrates is continuously processing sensory information relayed from the periphery, integrating it and producing outputs transmitted to efferents. In the brain, neurons employ an array of messenger molecules to filter afferent information and finely regulate synaptic transmission. READ MORE

6. 4. GABA in the islets of Langerhans

   Author : Anna Wendt; Diabetes - öcellsexocytos; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; diabetologi; sekretion; Endokrinologi; Endocrinology; SLMV; paracrine regulation; LDCV; islets of Langerhans; autocrine regulation; GABA; diabetology;

   Abstract : GABA (γ-aminobutyric acid) is a well-known inhibitory neurotransmitter in the CNS. GABA is also present at high concentrations in the insulin-producing β-cells in the islets of Langerhans, but its function there is less clear. GABA is believed to accumulate in SLMVs (synaptic-like microvesicles). READ MORE

7. 5. Deciphering the interplay between peripheral and central cytokine- and kynurenine pathways : importance for the pathophysiology of schizophrenia

   Author : Funda Orhan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Growing evidence suggests a role of low-grade inflammation in the pathophysiology of schizophrenia, giving rise to a dysregulation in neurons containing dopamine and glutamate as well as γ-aminobutyric acid (GABA). In this thesis, a role of peripheral and brain-immune signaling molecules, as well as brain neurotransmitters, was investigated in a wellcharacterized cohort of first-episode psychosis (FEP) patients. READ MORE