Search for dissertations about: "19F NMR spectroscopy"

Showing result 1 - 5 of 9 swedish dissertations containing the words 19F NMR spectroscopy.

2. 1. Studies of protein structure, dynamics and protein-ligand interactions using NMR spectroscopy

   Author : Tobias Tengel; Göran Larsson; Maria Sunnerhagen; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; 19F NMR; 2S albumin; PapD; protein-ligand interaction; structure; TFE; Yersinia; YopD; allergy; amphipathic helix; Ber e 1; Brazil nut; dynamics; FimC; LcrH; NMR screening; Biophysics; Biofysik;

   Abstract : In the first part of the thesis, protein-ligand interactions were investigated using the chaperone LcrH, from Yersinia as target protein. The structure of a peptide encompassing the amphipathic domain (residue 278-300) of the protein YopD from Yersinia was determined by NMR in 40% TFE. READ MORE

4. 2. Solid-phase glycoconjugate synthesis : on-resin analysis with gel-phase ¹9F NMR spectroscopy

   Author : Mickael Mogemark; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Solid-phase synthesis; protective groups; linkers; monitoring; gel-phase; 19F NMR spectroscopy; carbohydrates; oligosaccharides; glycopeptides; Organisk kemi; Organic chemistry; Organisk kemi;

   Abstract : An efficient and versatile non-destructive method to analyze the progress of solid-phase glycoconjugate synthesis with gel-phase 19F NMR spectroscopy is described. The method relies on use of fluorinated linkers and building blocks carrying fluorinated protective groups. READ MORE

5. 3. Antigens derived from the mucin MUC1 : Solution and solid-phase synthesis of saccharides, peptides and glycopeptides

   Author : Maciej Pudelko; Mikael Elofsson; Fredrik Almqvist; Thisbe K. Lindhorst; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lactones; glycopeptides; signal peptide; neoglycolipid arrays; solid-phase synthesis; MUC1; gel-phase 19F NMR spectroscopy; fluorinated alpha-amino protective group; Organic chemistry; Organisk kemi;

   Abstract : Mucin is a term used to describe a large family of heavily glycosylated proteins which are present on the surfaces of secretory epithelial cells and are overexpressed by many carcinomas. Membrane-bound mucin MUC1 is of special interest. Its backbone consists of repeating units of twenty amino acids with five potential glycosylation sites. READ MORE

6. 4. Combinatorial Synthesis of Pilicides

   Author : Anette Svensson; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; gel-phase 19F NMR spectroscopy; fluorinated linkers; E. coli bacteria; pilicides; combinatorial chemistry; solid-phase synthesis; Organic chemistry; Organisk kemi;

   Abstract : This thesis describes a combinatorial approach to design and synthesis of three libraries of compounds, referred to as pilicides, designed to target periplasmic chaperones present in uropathogenic Escherichia coli bacteria that are the main cause of urinary tract infections. Periplasmic chaperones are required for assembly of adhesive organelles, i. READ MORE

7. 5. Glycoconjugates : Solid-phase synthesis and biological applications

   Author : Fredrik Wallner; Mikael Elofsson; Jan Kihlberg; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugate; Glycolipid; Solid-phase synthesis; Glycosylation; Gel-phase 19F-NMR spectroscopy; Fluorinated linker; Carbohydrat array; CD1; Organic chemistry; Organisk kemi;

   Abstract : Glycoconjugates are biologically important molecules with diverse functions. They consist of carbohydrates of varying size and complexity, attached to a non-sugar moiety as a lipid or a protein. Glycoconjugate structures are often very complex and their intricate biosynthetic pathways makes overexpression difficult. READ MORE