Search for dissertations about: "27-hydroxycholesterol"

Showing result 1 - 5 of 21 swedish dissertations containing the word 27-hydroxycholesterol.

  2. 1. Deciphering the role of 27-hydroxycholesterol in neurodegeneration

    Author : Muhammad Al Mustafa Ismail; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cholesterol is constantly attributed to neurodegenerative diseases including Alzheimer’s disease (AD). This is due to the association of high blood cholesterol and the consequences of cholesterol metabolism in these conditions. READ MORE

  4. 2. Brain cholesterol metabolism : a study of mouse and man

    Author : Maura Heverin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer s Disease; 27-hydroxycholesterol; CYP46A1; cholesterol homeostasis.;

    Abstract : The brain is the most cholesterol rich organ in the body and contains about one quarter of the body's total cholesterol. How this cholesterol and its metabolism affects the complex brain under normal and pathological conditions has been the focus of intense research in recent years due to its possible association with the development or progression of neurodegeneration. READ MORE

  5. 3. Implications of cholesterol and cholesterol-lowering therapy in Alzheimer's disease

    Author : Daniel Famer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer s disease; dietary cholesterol; rosuvastatin; apolipoprotein E; alpha-secretase; beta-secretase; alpha- beta-secretase ratio; soluble APPalpha; gliosis; microglial load; interleukin-6; caspase-3; body weight gain; lifestyle-preventive strategy; 24 S -hydroxycholesterol; 27-hydroxycholesterol;

    Abstract : BACKGROUND: Alzheimer's disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia. It is believed that the majority of all AD patients are affected by the sporadic form, thus caused by the combined effects of several risk factors, such as elevated cholesterol levels in midlife and deficiencies in the lipoprotein transporters apolipoprotein E (ApoE). READ MORE

  6. 4. Cytochrome P450 Enzymes in the Metabolism of Cholesterol and Cholesterol Derivatives

    Author : Maria Norlin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : Cholesterol is metabolized to a variety of important biological products in the body including bile acids and vitamin D. The present investigation is focused on enzymes that catalyze 7α-hydroxylation or 27-hydroxylation in the metabolism of cholesterol, oxysterols (side chain-hydroxylated derivatives of cholesterol) and vitamin D3. READ MORE

  7. 5. On the possible use of oxysterols for the diagnosis and evaluation of patients with neurological and neurodegenerative diseases

    Author : Valerio Leoni; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multiple sclerosis; Alzheimer s disease; oxysterol; central nervous system; gas chromatography-mass spectrometry; blood brain barrier; cholesterol;

    Abstract : Oxysterols are monooxygenated derivatives of cholesterol with a unique ability to pass lipophilic membranes and are involved in a number of elimination pathways for cholesterol. One of the major oxysterols in the circulation, 24S-hydroxycholesterol, is formed exclusively in the brain, mainly in neuronal cells. READ MORE