Search for dissertations about: "32P-postlabelling"

Showing result 1 - 5 of 7 swedish dissertations containing the word 32P-postlabelling.

2. 1. 32P-postlabelling analysis of complex DNA adducts in human tissues

   Author : Ke Yang; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Complex DNA adducts in humans originate from exogenous and endogenous sources. Polycyclic aromatic hydrocarbons (PAHs) are a large group of chemicals including many potent carcinogens. PAHs are ubiquitously present in the environment and PAH-DNA adducts have been extensively studied in humans. READ MORE

4. 2. DNA adducts formed by ethene and butadiene : quantitative analysis in rats and humans

   Author : Chunyan Zhao; Karolinska Institutet; Karolinska Institutet; []
   Keywords : DNA adducts; 32P-postlabelling; cancer; genotoxicity; ethene; ethylene oxide; 1; 3-butadiene; epoxybutanediol;

   Abstract : The present study has focused on DNA adduct formation by two important industrial and environmental chemicals, ethene and butadiene, in rats and humans. Ethene and butadiene are among the 50 chemicals produced in greatest volume in the United States. READ MORE

5. 3. Quantitative analysis of DNA adducts formed by some epoxides of industrial importance

   Author : Kamila Plná; Karolinska Institutet; Karolinska Institutet; []
   Keywords : DNA adducts; 32P-postlabelling; cancer; genotoxicity; occupational; epoxides; allyl glycidyl ether; propylene oxide; epichlorohydrin;

   Abstract : The work presented herein has focused on DNA adduct formation by three industrial epoxides, allyl glycidyl ether, propylene oxide and epichlorohydrin. Epoxides, owing to the strained oxirane ring are chemically reactive and can alkylate various sites in DNA. READ MORE

6. 4. Analysis of DNA adducts formed by tamoxifen and related antiestrogenic and estrogenic compounds in rats

   Author : Heli Rajaniemi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : DNA adducts; 32P-postlabelling; tamoxifen; toremifene; diethylstilbestrol; clomiphene; triparanol; raloxifene; antiestrogen; estrogen; SERM; genotoxicity; cancer;

   Abstract : The work presented herein has focused on DNA adduct formation by the non-steroidal antiestrogen tamoxifen and its analogues. Tamoxifen, [(Z)-1-{4-[2-(dimethylamino)-ethoxy]phenyl}-1,2-diphenyl-1-butene], is widely used in the treatment of breast cancer and its recognised side effect is endometrial cancer. READ MORE

7. 5. Analysis of DNA adducts of some low molecular weight aldehydes : methods development and application in human biomonitoring

   Author : Jia-Long Fang; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Malondialdehyde (MA), acetaldehyde (Aa) and methylglyoxal (MG) are ubiquitously present in the environment and endogenously formed in animals and humans. They have been shown to be genotoxic and to readily react with DNA to form DNA adducts under physiological conditions. READ MORE