Search for dissertations about: "5 -oligoadenylate synthetase"

Showing result 1 - 5 of 30 swedish dissertations containing the words 5 -oligoadenylate synthetase.

  2. 1. Hit Identification and Hit Expansion in Antituberculosis Drug Discovery : Design and Synthesis of Glutamine Synthetase and 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors

    Author : Anneli Nordqvist; Anders Karlén; Mats Larhed; Anders Hallberg; Anna Linusson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tuberculosis; Glutamine synthetase; Imidazo[1; 2-a]pyridine analogues; Focused hierarchical design of experiments; DXR; Fosmidomycin analogues; 1-Deoxy-D-xylulose-5-phosphate reductoisomerase; Cinnamaldehydes; Oxidative Heck reaction; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Since the discovery of Mycobacterium tuberculosis (Mtb) as the bacterial agent causing tuberculosis, the permanent eradication of this disease has proven challenging. Although a number of drugs exist for the treatment of tuberculosis, 1.7 million people still die every year from this infection. READ MORE

  4. 2. Regulation of Glutamine Synthetase in the Diazotroph Rhodospirillum rubrum

    Author : Anders Jonsson; Stefan Nordlund; Karl Forchhammer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; glutamine synthetase; Rhodospirillum rubrum; GlnE; PII; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : The bacterial cell needs ammonia for synthesis of glutamine from glutamate. Only one enzyme is able to catalyze this reaction, namely glutamine synthetase (GS). GS can be regulated both transcriptionally and post-translationally and it is present in all kingdoms of life. READ MORE

  5. 3. Synthetic and structural studies of KDO-analogues : a new inhibitor of CMP-KDO synthetase

    Author : Kristina Luthman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  6. 4. Molecular aspects of glutathione synthetase deficiency

    Author : Runa Vidar Njålsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glutathione synthetase; kinetics; cooperativity; substrate affinity; splice mutations; phenotype; genotype;

    Abstract : The tripeptide glutathione (GSH) is involved in several crucial pathways in the cell, for instance regulation of enzyme activity, DNA synthesis, and free radical scavenging. Synthesis of GSH takes place via two steps in the gamma-glutamyl cycle. READ MORE

  7. 5. Molecular genetic studies of three autosomal recessive disorders : Sjögren-Larsson syndrome, glutathione synthetase deficiency and congenital ichthyosis

    Author : Maritta Pigg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Sjögren-Larsson syndrome; glutathione synthetase deficiency; congenital ichthyosis; linkage analysis; allelic association; mutation analysis; transglutaminase 1 gene; Genetik; Clinical genetics; Klinisk genetik; Clinical Genetics; klinisk genetik;

    Abstract : Investigations at the DNA level were performed in order to characterise the molecular basis forthree genetic disorders:Sjögren-Larsson syndrome (SLS) is characterised by congenital ichthyosis and severeneurological symptoms. Linkage analysis and allelic association of 24 Swedish families affectedby SLS showed linkage between the disease and the marker D17S805 on chromosome 17. READ MORE