Search for dissertations about: "6-mercaptopurine"

Showing result 1 - 5 of 9 swedish dissertations containing the word 6-mercaptopurine.

  2. 1. Clinical studies of thiopurine metabolism in inflammatory bowel disease

    Author : Ulf Hindorf; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastroenterologi; Gastro-enterology; thiopurine methyltransferase; 6-mercaptopurine; azathioprine; Inflammatory bowel disease; thiopurines; adverse events; methylated metabolites; thioguanine nucleotides;

    Abstract : Inflammatory bowel disease (IBD, i.e. primarily Crohn's disease and ulcerative colitis) is characterised by a chronic or relapsing inflammation of the digestive tract. READ MORE

  4. 2. Epidemiological and therapeutic aspects of Inflammatory Bowel Disease

    Author : Carl Eriksson; Jonas Halfvarson; Scott Montgomery; Flemming Bendtsen; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammatory bowel disease; ulcerative colitis; Crohn’s disease; cohort study; population-based; colectomy; disease course; anaemia; azathioprine; 6-mercaptopurine; vedolizumab;

    Abstract : Introduction: The two main forms of inflammatory bowel disease (IBD) are Crohn’s disease and ulcerative colitis. These are chronic inflammatory disorders, mainly affecting the gastrointestinal tract. READ MORE

  5. 3. Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine

    Author : Alan Kambiz Fotoohi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The goal of this thesis has been to elucidate the mechanisms underlying resistance to methotrexate (MTX), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG), the antimetabolites widely used in treatment of childhood leukemia, as well as to determine the influence of 7-hydroxymethotrexate (7-OHMTX), the major metabolite of MTX, on the therapeutic action of MTX. Resistant sublines of leukemic cell lines were developed by long-term exposure to stepwise increasing concentrations of these different agents. READ MORE

  6. 4. Pharmacogenetic studies of thiopurines : focus on thiopurine methyltransferase

    Author : Malin Lindqvist Appell; Michel Eichelbaum; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Pharmacogenetics represents the study ofvariability in drug response due to genetic variations. The thiopurines (6-mercaptopurine, 6-thioguanine and azathioprine) are prodrugs which require metabolic transformation to exert effect. READ MORE

  7. 5. Development of new methodology for therapeutic drug monitoring of thiopurine treatment

    Author : Svante Vikingsson; Curt Peterson; Björn Carlsson; Martin Josefsson; Sven Almer; Johan Ahlner; Lynne Lennard; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thiopurines; mercaptopurine; thioguanine; azathioprine; crohn s disease; ulcertive colitis; HPLC; TGN;

    Abstract : The three thiopurine drugs azathioprine (AZA), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are used to treat several diseases, including inflammatory bowel disease (IBD). They are pro-drugs and are believed to act through the formation of thioguanine nucleotides (TGNs). READ MORE