Search for dissertations about: "68Ga DOTA"

Showing result 1 - 5 of 15 swedish dissertations containing the words 68Ga DOTA.

  2. 1. Development of 18F- and 68Ga-Labelled Tracers : Design Perspectives and the Search for Faster Synthesis

    Author : Elisabeth Blom; Bengt Långström; Oleksiy Itsenko; Irina Velikyan; Farhad Karimi; Frank Rösch; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PET; nucleophilic 18F-fluorination; perfluoro; F-SPE; molecular design; 68Ga; chelators; DOTA; NOTA; microwave; halogen exchange; harmine; biotin; RGD; VEGF; CRP; Chemistry; Kemi; Organisk kemi; Organic Chemistry;

    Abstract : This thesis deals with the design of 18F- and 68Ga-labelled positron emission tomography (PET) tracers and the development of technologies that enable faster and simpler preparation with high specific radioactivity. Techniques like microwave heating and reducing the concentrations of the precursor were investigated with this perspective. READ MORE

  4. 2. Synthesis, Characterisation and Application of 68Ga-labelled Macromolecules

    Author : Irina Velikyan; Bengt Långström; Mats Bergström; Helmut Maecke; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; 68Ga; 68Ge 68Ga generator; radiolabelling; microwave heating; specific radioactivity; peptide; protein; antibody; oligonucleotide; positron emission tomography; tumour; Kemi; Chemistry; Kemi;

    Abstract : The positron emitting radionuclide 68Ga (T1/2 = 68 min) might become of practical interest for clinical positron emission tomography (PET). The metallic cation, 68Ga(III), is suitable for complexation with chelators, either naked or conjugated with biological macromolecules. READ MORE

  5. 3. Labelling of various macromolecules using positron emitting 76Br and 68Ga : Synthesis and characterisation

    Author : Ulrika Yngve; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; 76Br; Radiobromination; Prosthetic Groups; Macromolecules; Oligonucleotides; 68Ga; PET; Octreotide; Metal Chelates; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Abstract : Different prosthetic groups containing a trialkylstannyl- and an electrophilic group have been synthesised and labelled with the accelerator produced 76Br (T1/2=16 h) through oxidative bromination. The labelled prosthetic groups were conjugated to amino-containing macromolecules such as proteins and 5´-modified oligonucleotides. READ MORE

  6. 4. Synthesis, Characterization and Application of 68Ga-labelled Peptides and Oligonucleotides

    Author : Irina Velikyan; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi;

    Abstract : The positron emitting 68Ga radionuclide (T1/2 = 68 min) has the potential of practical interest for clinical PET. The metallic cation, 68Ga3+, is suitable for complexation reactions with chelators either naked or conjugated with macromolecules such as peptides and oligonucleotides. READ MORE

  7. 5. The Importance of Dosimetry and Radiobiology in Nuclear Medicine : Quantitative methods and modelling

    Author : Anna Stenvall; Lund Medicinsk strålningsfysik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Nuclear medicine; radionuclide therapy; radiopharmaceutical therapy; dosimetry; Monte Carlo modelling; radiobiology; ; γH2AX; DOTA-TATE; PET; SPECT;

    Abstract : Nuclear medicine uses radioactive pharmaceuticals for diagnostic or therapeutic purposes. The ionizing radiation emitted from the radiopharmaceutical is partially absorbed within the patient's body and internal dosimetry is the method to estimate the absorbed dose to a tumour or risk organ. READ MORE