Search for dissertations about: "ADH"

Showing result 1 - 5 of 30 swedish dissertations containing the word ADH.

  2. 1. Characterization and Directed Evolution of an Alcohol Dehydrogenase : A Study Towards Understanding of Three Central Aspects of Substrate Selectivity

    Author : Emil Hamnevik; Mikael Widersten; Gerrit Poelarends; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alcohol dehydrogenase; ADH-A; Biocatalysis; Directed evolution; Enantioselectivity; Enzyme kinetics; Enzyme mechanisms; Protein Engineering; Regioselectivity; Substrate selectivity; Biokemi; Biochemistry;

    Abstract : Many different chemicals are used in the everyday life, like detergents and pharmaceuticals. However, their production has a big impact on health and environment as much of the raw materials are not renewable and the standard ways of production in many cases includes toxic and environmentally hazardous components. READ MORE

  4. 2. The influence of temperature on enzyme selectivity in organic media

    Author : Åsa Jönsson; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; water activity; sub-zero temperatures; enantioselectivity; peptide yields; asymmetric reductions of ketones; peptide synthesis; ADH from Thermoanaerobium brockii; subtilisin; Enzyme catalysis; a-chymotrypsin; organic solvent; aqueous media; Biotechnology; Bioteknik;

    Abstract : The influence of different reaction parameters on enzyme selectivity was investigated. The reaction conditions studied were solvent dependence, water activity and reaction temperature. READ MORE

  5. 3. Studies on 5-hydroxytryptophol and the metabolic interaction between serotonin and ethanol

    Author : Margareta Some; Karolinska Institutet; Karolinska Institutet; []
    Keywords : serotonin; 5-hydroxytryptophol; 5-hydroxyindoleacetic acid; ethanol; metabolism;

    Abstract : The biogenic amine serotonin (5-hydroxytryptamine, 5HT) is most abundant within the gastrointestinal tract (GIT), in blood platelets, and in the central nervous system. The 5HT system is involved in many physiological and behavioural processes in the body. READ MORE

  6. 4. Enzymatic studies of alcohol dehydrogenase by a combination of in vitro and in silico methods

    Author : Mikko Hellgren; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Karolinska Institutet Department of Medical Biochemistry and Biophysics; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The family of alcohol dehydrogenases (ADHs) catalyzes conversions of alcohols, ketons and aldehydes. The early discovery and isolation of ADH (1937) was followed by numerous investigations. It was also the first dimeric enzyme for which the threedimensional structure was determined (1974). READ MORE

  7. 5. Clinical Pharmacokinetics of Small Doses of Ethanol : Role of Gastric Emptying and Other Influences in the Upper Gastrointestinal Tract

    Author : Stergios Kechagias; Risto Roine; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : This thesis deals with the clinical pharmacokinetics of small doses of ethanol as influenced by conditions in the proximal gut. The bioavailability of orally administered ethanol depends to a large extent on gastric emptying, which is influenced by pre-treatment with drugs and other clinically relevant factors in the upper gastrointestinal tract. READ MORE