Search for dissertations about: "ADP regulation of insulin secretion and beta-cell apoptosis"

Found 3 swedish dissertations containing the words ADP regulation of insulin secretion and beta-cell apoptosis.

  2. 1. ADP regulation of insulin secretion and beta-cell apoptosis

    Author : Chanyuan Tan; Kardiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; P2Y; β-cell; ADP; insulin; apoptosis; autocrine; ectonucleotidase;

    Abstract : The aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 and P2Y13 were shown in both mouse pancreatic islets and isolated β-cells using real-time PCR quantification. READ MORE

  4. 2. Role of inositol pyrophosphates in pancreatic beta cell function

    Author : Subu Surendran Rajasekaran; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Inositol pyrophosphates are high energy diphosphate containing molecules that are ubiquitous in eukaryotic cells. They have been implicated in diverse cellular processes ranging from DNA repair, telomere length regulation, ribosome synthesis, cell cycle regulation and apoptosis to osmoregulation, phosphate homeostasis, insulin sensitivity, vesicle trafficking, cytoskeletal rearrangement and exocytosis. READ MORE

  5. 3. Effects of imidazoline compounds on intracellular CA2+ and apoptosis

    Author : Ioulia Appelskog; Karolinska Institutet; Karolinska Institutet; []
    Keywords : imidazolines; imidazoline site; sulfonylurea; glucose; interleukin-1beta; insulin secretion; glucagon; somatostatin; pancreatic islets; pancreatic P-cells; HIT-T15 cells; apoptosis; cytoplasmic free Ca2 concentration;

    Abstract : Cytoplasmic free Ca2+ concentration ([Ca2+]i) plays a pivotal role in the regulation of insulin release from the pancreatic beta-cell. [Ca2+]i is also important in the control of apoptosis. READ MORE