Search for dissertations about: "ALS"

Showing result 1 - 5 of 72 swedish dissertations containing the word ALS.

  1. 1. ALS – a Clinical Thesis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ingela Nygren; Uppsala universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; ALS; epidemiology; drug sales statistics; QoL; growth factors; polyamines; Neurovetenskap; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Neurology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Neurologi;

    Abstract : Amyotrophic lateral sclerosis (ALS) is characterized by a progressive loss of upper and lower motor neurons, resulting in muscle weakness and death from respiratory failure within 3-5 years after onset. The incidence is 1.5-2.7/100,000 inhabitants. READ MORE

  2. 2. On the aetiology of ALS a comprehensive genetic study

    University dissertation from Umeå : Umeå Universitet

    Author : Caroline Ingre; Umeå universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; risk factor; VAPB; SOD1; amyotrophic lateral sclerosis; ATXN2; SMN1; SMN2; PFN1; 50 bp deletion in SOD1 promotor; population-specific genetic variations; Neurology; neurologi;

    Abstract : Introduction: Amyotrophic lateral sclerosis (ALS) is a deadly, progressive neuromuscular disease that affects individuals all over the world. About 10% of the patients have a familial predisposition (FALS) while the remainder of cases are isolated or sporadic (SALS) and of unknown cause. READ MORE

  3. 3. Zinc in folding and misfolding of SOD1 Implications for ALS

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Lina Leinartaité; Stockholms universitet.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein stability; protein misfolding; local unfolding; metal binding; energy landscape; protein disease; amyotrophic lateral sclerosis; biokemi; Biochemistry;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing degeneration of upper and lower motor neurons. Most ALS cases are sporadic; only 6% are associated with mutations in Cu, Zn superoxide dismutase (SOD1). READ MORE

  4. 4. Search for Biomarkers in ALS and Parkinson's Disease Positron Emission Tomography and Cerebrospinal Fluid Studies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anders Johansson; Uppsala universitet.; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyotrophic lateral sclerosis; ALS; Parkinson’s disease; cerebrospinal fluid; positron emission tomography; vascular endothelial growth factor; fibroblast growth factor 2; proteomics; Fourier transform ion cyclotron resonance mass spectrometry; deprenyl-D2; PIB; FDG; L-[β11C]-DOPA; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Neurology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Neurologi; Neurology; neurologi;

    Abstract : New biomarkers are needed to improve knowledge about pathophysiology, in order to provide earlier correct diagnosis and to follow disease progression of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). The aim of this thesis was to find new biomarkers for these diseases. READ MORE

  5. 5. SOD1´s Law An Investigation of ALS Provoking Properties in SOD1

    University dissertation from Umeå : Kemiska instsitutionen, Umeå universitet

    Author : Roberth Byström; Umeå universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; amyotrophic lateral sclerosis; SOD1; protein folding; membrane interaction; aggregates; survival time; repulsive charge; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi;

    Abstract : Proteins are the most important molecules in the cell since they take care of most of the biological functions which resemble life. To ensure that everything is working properly the cell has a rigorous control system to monitor the proper function of its proteins and sends old or dysfunctional proteins for degradation. READ MORE