Search for dissertations about: "AMPA receptor"

Showing result 16 - 20 of 40 swedish dissertations containing the words AMPA receptor.

2. 16. Utility of combined treatment with antipsychotic and antidepressant drugs : scientific rationales and clinical implications

   Author : Carl Björkholm; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The atypical antipsychotic drug (APD) clozapine is the most efficacious APD in treatment-resistant schizophrenia including negative symptoms and cognitive impairment, and still lacks extrapyramidal side effects (EPS). Clozapine, which also possesses an antidepressant effect and can be used as monotherapy in bipolar disorder, has a broad receptor binding profile with higher affinity for the α2-adrenoceptor and several serotonergic receptors than D2 receptor, enhances dopamine output in the medial prefrontal cortex (mPFC) and facilitates glutamatergic NMDA receptor-mediated transmission in pyramidal cells in the same brain region. READ MORE

4. 17. GABA-, glycine- and glutamate-induced currents in rat medial preoptic neurons : functional interactions and modulation by capsaicin

   Author : Urban Karlsson; Staffan Johansson; Johannes Krupp; Bryndis Birnir; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; medial preoptic nucleus; synaptic transmission; glutamate; GABA; glycine; TRPV1; Physiology; Fysiologi;

   Abstract : The medial preoptic nucleus (MPN) of the hypothalamus plays a major role in many functions involved in maintaining bodily homeostasis, such as thermoregulation and osmoregulation, as well as in the control of complex behaviours, e.g. sexual behaviour. READ MORE

5. 18. K+ channels and the regulation of synaptic transmission

   Author : Evanthia Nanou; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Neuronal excitability is highly regulated by K+ channels that are activated by a voltage change across the plasma membrane or by a rise in intracellular Na+ or Ca2+ concentration. The main focus of this thesis has been to characterize the Na+-activated K+ (KNa) and the Ca2+-activated K+ (KCa) channels and to determine their role in regulating synaptic transmission in the lamprey spinal cord. READ MORE

6. 19. On Fever Mechanisms & Preoptic Signalling

   Author : Anna Sundgren Andersson; Robert Dantzer; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

   Abstract : Fever, a 1-4 °C elevation of the body temperature, is part of the systemic inflammatory response to infection or tissue damage, and it is believed to be a potent host defence. The underlying physiological mechanisms of the febrile response are one of the two main objectives in this thesis, where studies conducted in whole animals (rats and mice), chiefly aimed at clarifying the cytokine cascade in fever. READ MORE

7. 20. Glutamate and GABA signalling components in the human brain and in immune cells

   Author : Amol K. Bhandage; Bryndis Birnir; Gerard P. Ahern; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neuroscience; Neurovetenskap; Immunologi; Immunology;

   Abstract : Glutamate and γ-aminobutyric acid (GABA) are the principal excitatory and inhibitory neurotransmitters in the central nervous system (CNS). They both can activate their ionotropic and metabotropic receptors. READ MORE