Search for dissertations about: "AMPA receptor"

Showing result 21 - 25 of 40 swedish dissertations containing the words AMPA receptor.

2. 21. Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids

   Author : Abdullahi Warsame Afrah; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Axotomy; Inflammation; Long term potentiation; Capsaicin; Opioids; Cholecystokinin; Substance P; Glutamate; NMDA; Spinal cord; Microdialysis; Radioimmunoassay.;

   Abstract : Nerve injury and tissue inflammation may lead to exaggerated responses to both noxious stimuli (hyperalgesia) and innocuous stimuli (allodynia). Altered release pattems of neurotransmitters in the dorsal hom of the spinal cord have been suggested to contribute to hyperalgesia and allodynia. READ MORE

4. 22. Afferent input to midbrain dopamine neurones and its modulation : an electrophysiological study i vitro

   Author : Pernilla Grillner; Karolinska Institutet; Karolinska Institutet; []
   Keywords : dopamine neurones; synaptic transmission; NMDA receptors; L-type Ca2 channels; presynaptic inhibition; metabotropic glutamate receptors; muscarine; nicotine;

   Abstract : Dopamine (DA) neurones of the ventral mesencephalon are involved in the control of reward related behaviour, cognitive functions and motor performances, and provide a critical site of action for major categories of neuropsychiatric drugs, such as antipsychotic agents, dependence producing drugs and anti-Parkinson medication. The midbrain DA neurones are mainly located in the substantia nigra pars compacta (SNPC) and the ventral tegmental area (VTA). READ MORE

5. 23. Studies on antidepressant-mediated regulation of signal transduction

   Author : Hongshi Qi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Depression affects around 16% of the population at some point in their lives and major depressive disorder is a leading cause of disability worldwide. Depression is caused by an interaction of genetic and environmental factors, but the molecular and cellular mechanisms underlying its pathogenesis are not entirely clear. READ MORE

6. 24. Regulation by glutamate- and adenosine-receptors of dopamine and acetylcholine release from rat striatal slices

   Author : Shaoyu Jin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : striatum; dopamine; acetylcholine; adenosine receptors; glutamatereceptors. ISBN 91-628-2599-2;

   Abstract : The striatum, which is critically involved in sensory motor integration, receives an excitatory glutamatergic input from the cerebral cortex and the thalamus. The effects of the glutamatergic stimulation are modulated by dopamine (DA) released from a prominent dopaminergic input, acetylcholine (ACh) released from cholinergic interneurons and by the ubiquitous neuromodulator adenosine. READ MORE

7. 25. Design and Synthesis of Angiotensin IV Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP)

   Author : Hanna Andersson; Anders Hallberg; Anders Karlén; Federico Corelli; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiotensin IV; AT4; insulin-regulated aminopeptidase IRAP ; inhibitor; peptidomimetics; γ-turn mimetic; macrocycle; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

   Abstract : Peptidomimetics derived from the bioactive hexapeptide angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) have been designed and synthesized. These peptidomimetics are aimed at inhibiting the insulin-regulated amino peptidase (IRAP), also known as the AT4 receptor. READ MORE