Search for dissertations about: "ANTINOCICEPTIVE"

Showing result 1 - 5 of 23 swedish dissertations containing the word ANTINOCICEPTIVE.

  2. 1. Characterization of the antinociceptive effects of morphine and its glucuronides : Pharmacokinetic-pharmacodynamic modeling

    Author : Marie Gårdmark; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Abstract : Pharmacodynamic modeling was used to quantify the time aspects of theantinociceptive effect in rats following administration of morphine, morphine-3-glucuronide (M3G) and morphine-glucuronide (M6G). M6G acts as a potentagonist of morphine actions, whereas the pharmacodynamic role of M3G has beenunclear. READ MORE

  4. 2. Pharmacokinetic and pharmacodynamic studies of morphine and morphine-3-glucuronide in rats : including validation and application of the microdialysis technique and time dependency of antinociceptive effects

    Author : Marianne Ekblom; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  5. 3. The role of adenosine and its receptor subtypes in nociception and neuropathic pain

    Author : Weiping Wu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adenosine; adenosine receptors; antinociception; caffeine; knock-out mouse; neuropathy; morphine; R-PIA;

    Abstract : As neurotransmitter/modulator, adenosine plays an important role in nociceptive processing. Adenosine receptors are G-protein coupled and four receptor subtypes, A1, A2A, A2B and A3 have been identified. It is well established that adenosine and its receptor agonists produce primarily antinociceptive effect in animals and humans. READ MORE

  6. 4. The analgesic mechanisms of buprenorphine

    Author : Poli Francois Kouya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Buprenorphine; morphine; cross-tolerance; g- opioid receptors; inbred mice.;

    Abstract : Buprenorphine, a derivative of thebaine, is a semi-synthetic opiate and a partial p-opioid receptor agonist. Buprenorphine is also a weak kappa-opioid receptor antagonist. Buprenorphine is used clinically as an analgesic and for maintenance therapy of opiate-dependent subjects because it produces limited withdrawal symptoms. READ MORE

  7. 5. Microdialysis as a tool in pharmacokinetic-pharmacodynamic studies investigating the brain distribution and effect delay of morphine and morphine-6-glucuronide

    Author : Marcel René Bouw; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Abstract : The microdialysis technique was developed as a tool for studying the pharmacokinetic and pharmacodynamicrelationships of morphine and morphine-6-glucronide (M6G). Concentrations of unbound drug in blood andbrain were monitored in order to elucidate the origin of the observed delay in antinociceptive effect in rats. READ MORE