Search for dissertations about: "ASNA1"

Found 3 swedish dissertations containing the word ASNA1.

  2. 1. ASNA1 and cisplatin resistance : studies in C. elegans and in human tumor cells

    Author : Oskar Hemmingsson; Peter Naredi; Mef Nilbert; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ASNA1; Cisplatin; C. elegans; Drug resistance; Apoptosis; Surgery; Kirurgi; Oncology; Onkologi; Surgery; kirurgi; Oncology; onkologi; cellforskning; cell research;

    Abstract : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. READ MORE

  4. 2. New modifiers of insulin signalling identified by interaction screens with ASNA-1 in C. elegans

    Author : Balasubramanian Natarajan; Peter Naredi; Richard Padgett; Umeå universitet; []
    Keywords : Insulin; C. elegans; ASNA1; Cisplatin; GRP94; unfolded protein response; SMN1; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Abstract : Background: Insulin is a hormone released by the pancreatic beta cells in response to elevated levels of nutrients in the blood. Insulin triggers the uptake of glucose, fatty acids and amino acids into the liver, adipose tissue and muscles. READ MORE

  5. 3. Insulin secretion and ASNA-1-dependent function of the endoplasmic reticulum in C. elegans

    Author : Ola Billing; Gautam Kao; Jussi Jäntti; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell research; cellforskning; genetik; Genetics;

    Abstract : ASNA1 is a well-conserved ATPase involved in a wide range of functions, including cisplatin resistance, growth control, insulin secretion and targeting of tail-anchored (TA) proteins to membranes. It is a positive regulator of insulin secretion both in the roundworm Caenorhabditis elegans and in humans. READ MORE