Search for dissertations about: "Acamprosate"

Found 5 swedish dissertations containing the word Acamprosate.

  2. 1. Brain glycine receptors as a common target for alcohol and the relapse-preventing drug acamprosate - a preclinical study

    Author : Pei Pei Chau; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alcoholism; Acamprosate; Glycine receptor; Preclinical study; Dopamine; Ethanol;

    Abstract : Alcohol abuse and dependence make up the most prevalent categories of substance use disorders in the world. Converging evidence from the current research group has identified two receptor populations, the glycine (GlyRs) and nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine system, as two potentially important targets for the development of new medication to treat alcohol dependence. READ MORE

  4. 2. Studies of acamprosate for the treatment of alcohol dependence

    Author : Anders Hammarberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alcohol dependence is a widespread psychiatric disorder with a prevalence of 4-6% in the adult population in western countries. Acamprosate (Calcium acetyl homotaurinate) is approved in many countries as a medication for the treatment of alcohol dependence. READ MORE

  5. 3. Placebo, alcohol and flumazenil provocations : subjective and objective registrations in psychopharmacological experiments

    Author : Lars Saxon; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Abuse and dependency of alcohol or drugs is a major problem today, with severe implications for society as well as for the individual. Treatment is often characterised by hard work and the road to recovery is (among other problems) paved with acute and protracted withdrawal symptoms as well as relapse. READ MORE

  6. 4. Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence

    Author : Helga Lidö Höifödt; Göteborgs universitet; []
    Keywords : Psykiatri experimentell ; Neurofarmakologi; alcohol; dependence; dopamine; GlyT-1 inhibition; nucleus accumbens; reward;

    Abstract : Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter systems. READ MORE

  7. 5. Gene expression profiling in animal models of alcoholism

    Author : Christina Arlinde; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alcoholism; gene expression; microarray; animal model; rat; brain;

    Abstract : Genetic and environmental factors in alcoholism interact at the level of the transcriptome to encode the phenotypic traits of this complex clinical syndrome. Because of this, the prospect of simultaneous, genome wide, high-throughput analysis of gene expression in key brain areas potentially offers a novel strategy to identify new molecular treatment targets in this disease. READ MORE