Search for dissertations about: "Acetyl-CoA"

Showing result 1 - 5 of 16 swedish dissertations containing the word Acetyl-CoA.

  2. 1. Engineering cytosolic acetyl-CoA metabolism in Saccharomyces cerevisiae

    Author : Yiming Zhang; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; reverse engineering; flavodoxin; genomic DNA sequencing; ferredoxin; histone deacetylase; adaptive evolution; ferredoxin flavodoxin NADP reductase; pyruvate decarboxylase; citrate synthase; hexose transporter; yeast; mitochondria; aerobic growth; metabolic engineering.; acetyl-CoA; central carbon metabolism;

    Abstract : A Saccharomyces cerevisiae strain carrying deletions in all three pyruvate decarboxylase genes (also called Pdc negative yeast) represents a non-ethanol producing platform strain for biochemical production. However, it cannot grow on glucose as the sole carbon source due to the lack of cytosolic acetyl-CoA for lipid biosynthesis. READ MORE

  4. 2. Evaluation of precursor and cofactor engineering strategies influencing fatty acid metabolism in Saccharomyces cerevisiae

    Author : Alexandra Linda Bergman; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Saccharomyces cerevisiae; metabolic engineering; fatty acids; oleochemicals; NADPH; Sustainability; phosphoketolase; acetyl-CoA; transcription factor;

    Abstract : If humanity is to reduce the rate of climate change, it is essential that our societies switch to a more sustainable production of fuels and chemicals, which in turn depends on technological development. Oleochemical production via microbial catalysts – such as the yeast Saccharomyces cerevisiae – can use a considerably broader range of renewable substrates compared to the conventional production processes. READ MORE

  5. 3. Metabolic engineering of Saccharomyces cerevisiae for polyhydroxybutyrate production

    Author : Kanokarn Kocharin; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; S. cerevisiae; Acetyl-CoA; NADPH; Metabolic engineering; Polyhydroxybutyrate;

    Abstract : Establishing industrial biotechnology for the production of chemical compounds from the biosynthetic pathway has received a significant boost with the implementation of metabolic engineering. At present, metabolic engineering in Saccharomyces cerevisiae gains significant advantages of integration of knowledge acquired through a long history of use and data acquisition from novel –omics technologies hence enabling the development of a tailor-made S. READ MORE

  6. 4. Application of Synthetic Biology for Biopolymer Production using Saccharomyces cerevisiae

    Author : Alejandro Muñoz De Las Heras; Teknisk mikrobiologi; []
    Keywords : Saccharomyce cerevisiae; Xylose; Poly-3-d-hydroxybutyrate PHB ; NADH; NADPH; Acetyl-CoA; Metabolic engineering;

    Abstract : Plastics are versatile, cheap and durable materials that are omnipresent in modern society. Since most of them are derived from crude oil and are not biodegradable, their production leads to the depletion of fossil fuels and the accumulation of enormous amounts of plastic waste that pollutes ecosystems worldwide. READ MORE

  7. 5. Characterisation of two novel oleaginous yeast strains for efficient and sustainable production of acetyl-CoA derived products

    Author : Friederike Mierke; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Yeasts are major players in industry for production of valuable compounds. The market for yeast bioproduction is constantly growing, and sustainable bioproduction from renewable feedstocks is becoming increasingly important. READ MORE