Search for dissertations about: "Activating Protein-1"

Showing result 1 - 5 of 14 swedish dissertations containing the words Activating Protein-1.

  2. 1. Alcohol and gene expression in nerve cells with emphasis on transcription factor AP-1

    Author : Ulrik Fried; Institutionen för laboratoriemedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nerve cells; SH-SY5Y; muscarinic receptors; MAPKs; PKC; gene expression; jun; Activating Protein-1; Alcohol; ethanol; CRABP-I; Clinical chemistry; Klinisk kemi;

    Abstract : Alcohol induces profound effects on the function of the nerve cells in the nervous system. Alterations in gene expression is an important way by which these effects could be induced and sustained. Activating Protein-1 (AP-1) is a dimeric transcription factor constituted of proteins from the fos and jun immediate-early gene families. READ MORE

  4. 2. Transcriptional regulation of the latent membrane protein 1 gene by Epstein-Barr virus nuclear antigen 2

    Author : Lars Palmqvist; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; B-cell; transformation; LMP1; EBNA2; transcription; phosphorylation; histone acetylation;

    Abstract : The Epstein-Barr virus (EBV) is a ubiquitous human herpes virus, which infects B-cells. This leads to a life-long latent infection, which in most cases is non-pathogenic. However, EBV is etiologically associated with several human malignancies, including endemic Burkitt's lymphoma, nasopharyngeal carcinoma and post-transplant lymphoma. READ MORE

  5. 3. Mechanisms of endothelial cell dysfunction in Wegener's granulomatosis

    Author : Carolina Holmén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Wegener´s granulomatosis; vasculitis; anti-endothelial cell antibody; circulating endothelial cell; vascular adhesion protein 1; MHC class-I related chain A;

    Abstract : Vasculitides are a heterogeneous group of disorders that share a common feature of blood vessel inflammation. A major cell type of the blood vessel affected is the endothelial cell (EC). READ MORE

  6. 4. Aspects of the regulation of human sperm motility

    Author : Pär K G Leijonhufvud; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In this thesis I address some of the possible causes for oligozoospermia and low sperm motility, two factors that, singly or in combination, are often seen in cases of male subfertility. In the first study we evaluated the effect on human spermatozoa of the toxicity of compounds present in diesel exhaust. READ MORE

  7. 5. Application of Proximity Ligation Assay for Multidirectional Studies on Transforming Growth Factor-β Pathway

    Author : Agata Zieba; Ola Söderberg; Kathleen C. Flanders; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation; TGF-β signaling; Smad; single cell analysis; cell cycle; context-dependent signaling; CRC; Molekylär cellbiologi; Molecular Cellbiology; Medicinal Chemistry; Läkemedelskemi; Molecular Biology; Molekylärbiologi;

    Abstract : A comprehensive understanding of how the body and all its components function is essential when this knowledge is exploited for medical purposes. The achievements in biological and medical research during last decades has provided us with the complete human genome and identified signaling pathways that governs the cellular processes that facilitates the development and maintenance of higher order organisms. READ MORE