Search for dissertations about: "Active uptake transport"

Showing result 1 - 5 of 49 swedish dissertations containing the words Active uptake transport.

  2. 1. In Vivo Active Drug Uptake and Efflux at the Blood-Brain Barrier : With Focus on Drug Transport Interactions

    Author : Muhammad Waqas Sadiq; Margareta Hammarlund-Udenaes; Sven Björkman; N. Joan Abbott; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Active uptake transport; Microdialysis; P-glycoprotein; Drug interactions; Species differences; Pharmacokinetics; Pharmacodynamics; NONMEM; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : The blood-brain barrier (BBB) controls the movement of substances into and out of the brain. The tight junctions between endothelial cells and energy dependent transporters in the BBB influence rate and extent of drug distribution to the brain. READ MORE

  4. 2. Blood-Brain Barrier Transport : Investigation of Active Efflux using Positron Emission Tomography and Modelling Studies

    Author : Stina Syvänen; Margareta Hammarlund-Udenaes; Mats Bergström; Gunnar Blomquist; Jashvant Unadkat; Uppsala universitet; []
    Keywords : Pharmaceutical biosciences; pharmacokinetics; P-glycoprotein; blood-brain barrier; modelling; PET; active efflux; species differences; [11C]verapamil; drug development; Farmaceutisk biovetenskap;

    Abstract : This thesis examines the transport of exogenous molecules across the blood-brain barrier (BBB), focusing on active efflux, using positron emission tomography (PET), computer simulation and modelling. P-glycoprotein (P-gp) inhibition was studied using [11C]verapamil and [11C]hydroxyurea was investigated as a new marker for active efflux transport. READ MORE

  5. 3. Active Transport of Ions across Biomembranes : A Kinetic Study of Cytochrome c Oxidase Reconstituted into Phospholipid Vesicles

    Author : Kristina Faxén; Peter Brzezinski; Pia Ädelroth; Thomas E. DeCoursey; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cytochrome c oxidase; electron transfer; proton transfer; proton pumping; kinetic isotop effect; ion pumping; flow flash; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : Ion transport across membranes is of uttermost importance for us. It is the foundation for signaling of various kinds e.g. in the nerve-system. READ MORE

  6. 4. Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model

    Author : Sibylle Neuhoff; Per Artursson; Anna-Lena Ungell; Patrick Augustijns; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; Caco-2 cells; membrane permeability; drug permeation; drug efflux ratios; drug uptake ratios; Cremophor EL; bovine serum albumin; pH-dependent permeability; drug transport; FARMACI; PHARMACY; FARMACI;

    Abstract : Drug transport across the intestinal epithelium is roughly predicted from permeability values obtained from Caco-2 cell monolayers. This thesis examines the important role of pH and extracellular additives for increasing the reliability and predictivity of the in vitro screening system, Caco-2. READ MORE

  7. 5. Functional Characterization of Tyrosine Transporters in fibroblast from Healthy Controls and Schizophrenic Patients

    Author : Ravi Vumma; Nikolaos Venizelos; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibroblasts; Schizophrenia; Precursor of Dopamine; Biological Transport; Active cellphysiology; Tyrosine and alanine transport; System-L; LAT1; LAT2; LAT3; LAT4; MEDICINE; MEDICIN; Internal medicine; Invärtesmedicin; Neurology; Neurologi; Neurology; Neurologi;

    Abstract : Cultured human fibroblasts offer an advantageous system to investigate the amino acid transport properties without confounding the affects of disease state and its treatment in many systemic psychiatric disorders. In previous studies, fibroblast cells have been used to investigate the tyrosine transport across plasma membranes in patients with schizophrenia and autism with out characterizing the particular amino acid transporters. READ MORE