Search for dissertations about: "AhR genes"

Showing result 1 - 5 of 22 swedish dissertations containing the words AhR genes.

  2. 1. Evolution and Ecology of AhR genes in Atlantic salmon (Salmo salar L.)

    Author : Maria Hansson; Biodiversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; AhR genes; Atlantic salmon; gene evolution; phylogenetics; environmental pollutants; Baltic Sea; ecotoxicology; Animal ecology; Djurekologi;

    Abstract : In vertebrates, studies of the aryl hydrocarbon receptor (AhR) have been of particular interest due to its direct involvement in the toxic effects exerted by several environmental pollutants, such as PCB and dioxin. After binding to the toxic molecule, this receptor initiates transcription of several genes that are part of the biotransformation battery but most notably the cytochrome P450 (CYP) genes, which results in an excessive release of oxidative enzymes and free radicals. READ MORE

  4. 2. ENVIRONMENTAL CONTAMINANTS AND SPERM Y:X CHROMOSOME RATIO. Impact of androgen- and dioxin-related effects in vivo and in vitro

    Author : Tarmo Tiido; Malmö Reproduktionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AR; polymorphisms; Sertoli cell; endocrine disruption; inhibitory cross-talk; Biomedicinska vetenskaper; Biomedical sciences; AHR; sperm Y:X chromosome ratio; sex ratio; POPs; TCDD;

    Abstract : During the last decades, there has been concern that the environmental contaminants, such as POPs, may contribute to sex ratio changes in offspring of exposed populations. Accidental exposure to TCDD has been shown to be associated with fewer sons in men who were exposed in adolescence or earlier in life. READ MORE

  5. 3. Signaling via the bHLH-PAS proteins AhR and HIF

    Author : Cecilia Bosdotter; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis concerns some mechanistic properties of the basic helix-loop-helix/PAS (bHLH-PAS) factors aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1 alpha (HIF-1α). The bHLH-PAS family of proteins is a family of factors that controls a variety of developmental and physiological events. READ MORE

  6. 4. Identification of novel pathways of regulation of AHR and HIF-­1 function

    Author : Michael Gralla; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mammalian bHLH-Pas (basic HLH (helix-loop-helix)-PER-ARNT-SIM) proteins belong to the bHLH superfamily of transcription factors. Members of the family have a broad spectrum of functions that among others sense and regulate the cellular response to physiological signals such as low oxygen levels (hypoxia), or environmental signals such as toxins. READ MORE

  7. 5. The microbiome, PPARγ and AhR in the inflammation-metabolism interface within the gastrointestinal tract

    Author : Agata Korecka; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The mammalian body is a mosaic of different organisms - a holobiont, which contains all the biomolecules and their metabolites encoded in our eukaryotic genome and supplemented by an even larger pool of prokaryotic genes and products. This symbiotic coexistence is presumed to have evolved to necessitate the sharing of biological and biochemical needs important for growth, body physiology, survival and reproduction. READ MORE