Search for dissertations about: "Alphavirus"
Showing result 1 - 5 of 16 swedish dissertations containing the word Alphavirus.
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1. Alphavirus vectors as recombinant vaccines
Abstract : This thesis describes further developments of an expression system based on the alphavirus Semliki Forest virus (SFV), and its potential use as recombinant vaccine. The RNA genome of SFV contains a 3'open reading frame (ORF) encoding the structural proteins, and a 5' ORF coding for the viral replicase. READ MORE
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2. Protein interactions involved in alphavirus assembly
Abstract : Viruses have to protect their genomes during transport from the infected to an uninfected host cell. This is achieved by forming a protein shell around the nucleic acid. Virus assembly is a complex process that involves interactions with the viral genome, the viral structural proteins and for enveloped viruses a lipid membrane. READ MORE
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3. Alphavirus replicon-based strategies for vaccination
Abstract : Vaccination has been extremely successful for the control of many infectious diseases. However, efficient vaccines are still not available against diseases such as HIV, hepatitis C, malaria and tuberculosis. For these diseases, the traditional vaccine approaches are not feasible, and thus new vaccine technologies are needed. READ MORE
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4. Alphavirus-host interactions : how to unravel the proviral activity of G3BP
Abstract : The genus Alphavirus belongs to the virus family Togaviridiae, a group of arthropod-borne enveloped RNA viruses with single-stranded, positive-sense genome. Members of this genus can be found worldwide and are geographically distinguished into Old World and New World alphaviruses. READ MORE
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5. Exploration of host cells during old world alphavirus infection : modulation of RNA granules and the PI3K/AKT pathway
Abstract : As obligate intracellular parasites, viruses have to explore and modulate cellular pathways for their survival. Mechanistic studies of virus–host interactions provide a better understanding of viral infection and cellular responses and help to identify potential targets for therapeutic intervention. READ MORE