Search for dissertations about: "Amino alcohol"

Showing result 1 - 5 of 51 swedish dissertations containing the words Amino alcohol.

  2. 1. Amino Aacohols : stereoselective synthesis and applications in diversity-oriented synthesis

    Author : Staffan Torssell; Peter Somfai; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; amino alcohol; carbenoid; carbonyl ylide; cross-metathesis; diastereoselective; 1; 3-dipolar cycloaddition; sphingosine; Organisk kemi; Organic chemistry; Organisk kemi;

    Abstract : This thesis is divided into three separate parts with amino alcohols as the common feature. The first part describes the development of a novel three-component approach to the synthesis of α-hydroxy-β-amino esters. READ MORE

  4. 2. Stereoselective Synthesis of Amino Alcohols : Applications to Natural Product Synthesis

    Author : Staffan Torssell; Peter Somfai; Pher G Andersson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Amino alcohol; asymmetric 1.3-dipolar cycloaddition; azomethine ylide; carbenoid; carbonyl ylide; cross-metathesis; omuralide; oxazolidine; rhodium; sphingosine; stemoamide; stereoselective synthesis; total synthesis.; Organic chemistry; Organisk kemi;

    Abstract : This thesis is divided into four separate parts with amino alcohols as the common feature. The first part of the thesis describes the development of an efficient three-component approach to the synthesis of α-hydroxy-β-amino esters. READ MORE

  5. 3. Stereoselective Nucleophilic Additions to Aldehydes and Synthesis of α-Amino-β- Hydroxy-Esters

    Author : Jakob Danielsson; Peter Somfai; Hans Adolfsson; Tobias Rein; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Asymmetric induction; stereochemical models; Mukaiyama; polar Felkin-Anh; Cornforth-Evans; 1; 3-dipole; aziridine; cycloaddition; amino alcohol; carbonylation; Heck reaction; quaternary stereocenter;

    Abstract : This thesis deals with the development of new reaction methodology as well as stereochemical investigations. The first part concerns the investigation of 1,2- and merged 1,2- and 1,3- asymmetric induction in Mukaiyama aldol additions to α-heteroatom and α,β- heteroatom substituted aldehydes respectively. READ MORE

  6. 4. Oxidation of 1,2-Diols Using Alcohol Dehydrogenases : From Kinetic Characterization to Directed Evolution

    Author : Cecilia Blikstad; Mikael Widersten; Stefan Lutz; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; enzyme kinetics; alcohol dehydrogenase; directed evolution; enzyme engineering; diol; α-hydroxy aldehyde; Biokemi; Biochemistry;

    Abstract : The use of enzymes as catalysts for chemical transformations has emerged as a “greener” alternative to traditional organic synthesis. An issue to solve though, is that enzymes are designed by nature to catalyze reactions in a living cell and therefore, in many cases, do not meet the requirements of a suitable biocatalyst. READ MORE

  7. 5. Engineered Alcohol Dehydrogenases for Stereoselective Chemical Transformations

    Author : Thilak Reddy Enugala; Mikael Widersten; Manfred T. Reetz; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; alcohol dehydrogenase-A; biocatalysts; protein engineering; enzyme kinetics; sec-alcohols; ketones; stereoselectivity; regioselectivity; substrate selectivity and promiscuity.; Biokemi; Biochemistry;

    Abstract : Enzymes are biomolecules built from amino acids and catalyze the chemical transformations in a cell. Enzymes are by nature stereoselective, biodegradable, environmentally friendly, and can perform catalysis in aqueous solutions and at ambient temperatures. READ MORE