Search for dissertations about: "Anaplastic thyroid carcinoma"

Showing result 1 - 5 of 15 swedish dissertations containing the words Anaplastic thyroid carcinoma.

  2. 1. Taking Pressure of Anaplastic Thyroid Carcinoma : Molecular Studies of Apoptosis and Interstitial Hypertension

    Author : Pernilla Roswall; Nils-Erik Heldin; Kristofer Rubin; Sven Påhlman; Uppsala universitet; []
    Keywords : Medicine; Anaplastic thyroid carcinoma; Apoptosis; Cre recombinase; 2-Methoxyestradiol; Transforming growth factor-β; Transgenic mouse; Tumor-associated macrophages; Tumor interstitial fluid pressure; Medicin;

    Abstract : Molecular mechanisms in the development and progression of thyroid carcinomas are still not fully understood. In the present thesis the highly malignant anaplastic thyroid carcinoma (ATC) was used to study regulation of apoptosis and tumor interstitial fluid pressure (IFP). READ MORE

  4. 2. Tumor Stroma in Anaplastic Thyroid Carcinoma : Interstitial Collagen and Tumor Interstitial Fluid Pressure

    Author : Ellen Lammerts; Lucio Nitsch; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Collagen I synthesis; Fibrosis; Tumor - stroma interactions; PDGF; TGF-β; Inhibitor; Cell cycle; Tumor growth; Hyaluronan; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Abstract : Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy in man with stromal fibrosis as one of the main features. Carcinoma cells synthesized no or little collagen I protein. READ MORE

  5. 3. Regulatory Effects of TGF-β Superfamily Members on Normal and Neoplastic Thyroid Epithelial Cells

    Author : Åsa Franzén; Paschalis Sideras; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; activin; BMP; cadherin; carcinoma; cell cycle arrest; dedifferentiation; EGF; growth inhibition; invasion; Smad; TGF-β; thyroid; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Thyroid growth and function is partly regulated by growth factors binding to receptors on the cell surface. In the present thesis, the transforming growth factor-β (TGF-β) superfamily members have been studied for their role in regulation of growth and differentiation of both normal and neoplastic thyroid epithelial cells. READ MORE

  6. 4. Growth factor receptor signalling in thyrocytes of normal and neoplastic origin

    Author : Daniel Bergström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; thyroid; carcinoma; HGF; Met; TGF-β; EGF; receptor signalling; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Cellular growth and function are controlled by stimulatory and inhibitory factors actingthrough specific receptors. The present thesis focuses on the role of growth factors, theirreceptors and signalling pathways in normal and neoplastic thyroid epithelial cell biology. READ MORE

  7. 5. Genetic Characterization and Identification of Novel Treatment Targets in Anaplastic Thyroid Carcinoma

    Author : Naveen Ravi; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic thyroid cancer; copy number alterations; somatic mutations; mutational signatures; DNA methylation analysis; Gene expression analysis;

    Abstract : Anaplastic thyroid cancer (ATC) is a rare and highly aggressive thyroid malignancy, usually resistant to conventional therapeutic strategies. The prognosis of ATC is extremely poor with a median survival rate of 6 months. Current treatment therapy includes surgical resection in combination with external radiotherapy and chemotherapy. READ MORE