Search for dissertations about: "Artemisinin"

Showing result 1 - 5 of 34 swedish dissertations containing the word Artemisinin.

  2. 1. In vitro and in vivo studies of artemisinin endoperoxides

    Author : Therese Ericsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Artemisinin; Artesunate; Breast cancer; Cytochrome P450; Dihydroartemisinin; Inhibition; LC-MS MS; Pharmacokinetics; Plasma; Saliva;

    Abstract : Artemisinin and its semi-synthetic derivatives (eg. Artemether/ARM, artesunate/ARS, dihydroartemisinin/DHA) play an important role in combating malaria, and treatments containing an artemisinin derivative (artemisinin-based combination therapies, ACTs) are today the standard treatment worldwide for Plasmodium falciparum malaria. READ MORE

  4. 2. Clinical Pharmacokinetics of the Antimalarial Artemisinin Based on Saliva Sampling

    Author : Toufigh Gordi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Artemisinin; pharmacokinetics; saliva; HPLC; pharmacodynamics; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Biopharmaceutics; biofarmaci;

    Abstract : Artemisinin is the parent compound of a novel family of antimalarials. Repetitive administrations of artemisinin to both healthy volunteers and malaria patients have been shown to result in decreased plasma concentrations of the compound, most probably due to an autoinduction of different CYP450 enzymes. READ MORE

  5. 3. Cytochrome P450 enzymes affected by artemisinin antimalarials-pharmacokinetic and pharmacogenetic aspects

    Author : Sara Asimus; Göteborgs universitet; []
    Keywords : artemisinin; autoinduction; cytochrome P450; induction; inhibition; malaria; metabolism; pharmacogenetics; pharmacokinetics; probe;

    Abstract : With more than 500 million cases and at least 1 million deaths each year, malaria is a major global health problem. The main problem with malaria control is the emerging drug resistance among parasites causing the infection. Consequently, there is an urgent need for new drugs. READ MORE

  6. 4. Sesquiterpene synthases in Artemisia annua: Cloning, Expression, and Characterisation of the Recombinant Enzymes

    Author : Per Mercke; Kemiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Artemisia annua; Sesquiterpene synthases; artemisinin; Plant biochemistry; Växtbiokemi;

    Abstract : Plants produce a multitude of different compounds that may have biotic effects. Artemisia annua, produces a compound used as a drug against multi-drug-resistant strains of Plasmodium falciparum, the parasite causing malaria. READ MORE

  7. 5. Modelling and Simulation to Improve Antimalarial Therapy

    Author : Jesmin Permala Lohy Das; Mats Karlsson; Martin Bergstrand; Joel Tarning; Mads Krielgaard; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; pharmacokinetics; pharmacodynamics; malaria; artemisinin; weekly dosing; resistant; pregnant populations; intermittent preventive therapy; parasite clearance; day 3 positivity; nomogram; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-related mortality and morbidity during the past decade. Despite the widespread use of ACT, there is still a considerable knowledge gap with regards to safety, efficacy and pharmacokinetic properties of these drugs, particularly in vulnerable populations like children and pregnant women. READ MORE