Search for dissertations about: "B cell antigen receptor"

Showing result 21 - 25 of 158 swedish dissertations containing the words B cell antigen receptor.

  2. 21. CAR T cells for Immunotherapy of Cancer

    Author : Tina Sarén; Magnus Essand; Martin Pule; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chimeric antigen receptor CAR -T cells; Cancer immunotherapy; NAP; Tonic signaling; T cell exhaustion; B cell lymphoma; clinical trial; glioblastoma;

    Abstract : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. READ MORE

  4. 22. B cell activation in vitro: thymus-dependent immune responses and bacterial cell surface proteins

    Author : Karol Axcrona; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nuclear transport; bacterial Ig-binding proteins; CD40L promoter; CD21; Ig; B lymphocyte activation in vitro; CD40; Immunology; serology; transplantation; Immunologi; serologi;

    Abstract : In this thesis aspects of peripheral B lymphocyte differentiation were studied. Through in vitro experiments, B lymphocyte activation was assessed. B lymphocytes express immunoglobulin (Ig) specific for a certain antigen on the cell surface, and when surface Ig is crosslinked by an antigen, the cell is activated. READ MORE

  5. 23. Regulation of B cell responses to modified self

    Author : Emilie Grasset; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The immune system needs to be efficient to protect organisms from invading pathogens. Lymphoid organs such as the spleen and lymph nodes are needed to initiate the response. READ MORE

  6. 24. Immune regulation by selective estrogen receptor modulators

    Author : Angelina I Bernardi; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Endocrinology; Mice; Lasofoxifene; Bazedoxifene; Raloxifene; Estrogen; Osteoporosis; B cells; T cells; Rheumatoid arthritis;

    Abstract : At menopause, the levels of estrogen decline, leading to loss of estrogen-mediated protective effects on bone and an increased risk of osteoporosis. Hormone replacement therapy, containing estrogen, has been used for many years to prevent and treat osteoporosis in postmenopausal women. READ MORE

  7. 25. Structural Basis of Immune Receptor Binding by Staphylococcal Superantigens

    Author : Karin Rödström; Medicinsk strukturbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Superantigen; X-ray Crystallography; T cell receptor; Major histocompatibility complex;

    Abstract : Superantigens (SAgs) are toxins capable of inducing a massive immune response, leading to severe disease. They are secreted by the bacteria Staphylococcus aureus and Streptococcus pyogenes, which produce the staphylococcal enterotoxins and streptococcal pyogenic exotoxins, respectively. READ MORE