Search for dissertations about: "B cell depletion therapy"

Showing result 1 - 5 of 27 swedish dissertations containing the words B cell depletion therapy.

  2. 1. Dopamine neurons in ventral mesencephalon : interactions with glia and locus coeruleus

    Author : Elisabet Berglöf; Ingrid Strömberg; Stephen B. Dunnett; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; ventral mesencephalon; nerve fiber formation; glia; locus coeruleus; grafting; antioxidant-enriched diet; Histology; Histologi;

    Abstract : Parkinson’s disease is a progressive neurodegenerative disorder, characterized by a depletion of the dopaminergic neurons in the substantia nigra. The cause of the disease is yet unknown but age, oxidative stress, and neuroinflammation are some of the features involved in the degeneration. READ MORE

  4. 2. The role of B cells in rheumatoid arthritis

    Author : Maria Rehnberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cells; Rheumatoid arthritis; B cell depletion therapy;

    Abstract : It has been known for a long time that B cells play a role in rheumatoid arthritis (RA). By production of autoantibodies, presentation of auto-antigens and by producing cytokines B cells may contribute to the pathogenesis of RA. In recent years it has been shown that anti-B cell therapy is a powerful tool in the treatment of RA. READ MORE

  5. 3. Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy

    Author : Haisha Ma; Johan Lennartsson; Håkan Axelson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; Ras; macropinocytosis; Fer; STAT3; HD-PTP; Cbl; ubiquitination; pericyte; vasculature; tumor; ASKA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. READ MORE

  6. 4. B cell depleting therapy in systemic lupus erythematosus

    Author : Thórunn Jónsdóttir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Systemic Lupus Erythematosus; Lupus nephritis; B cells; rituximab;

    Abstract : Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by multiple organ involvement, production of a wide range of autoantibodies and local formation or tissue deposition of immune complexes in the affected organs. Lupus nephritis (LN) is a common and serious organ involvement in patients with SLE. READ MORE

  7. 5. Immune monitoring in humans after manipulation by B cell depletion and immunization

    Author : Therese Vallerskog; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The overall goal of this thesis was to study the influence of immunomodulatory drugs on the human immune system. The approach was bi-directional; ex vivo studies were performed after B cell depletion with rituximab treatment in patients with SLE and RA, and an in vivo assay was established to study effects of drugs on immune responsiveness. READ MORE