Search for dissertations about: "BETi"

Found 3 swedish dissertations containing the word BETi.

2. 1. Using genetics to identify epigenetic and signal transduction targets in cancer

   Author : Joydeep Bhadury; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; BETi; HDACi; ATRi; miRNA; NGS; PDX; CDX;

   Abstract : Cancer arises mostly due to the stepwise acquisition of untamed growth capabilities by various means, ranging from genetic, epigenetic to environmental factors. With the advancement made in molecular biology and associated fields, the complex biological circuits leading to these pathological conditions have now started to be deciphered in-depth. READ MORE

4. 2. Targeting Myc-driven tumours - BETing on ATR

   Author : Somsundar Veppil Muralidharan; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Cancer arises from loss of function of tumour suppressors and/or gain of function mutations in proto-oncogenes that disrupt the delicate balance required for homeostatic cell division, resulting in uncontrolled cell proliferation. Oncogenic transformation of multifaceted proto-oncogene - transcription factor - MYC can give rise to cancers and it is found to be deregulated in more than 70% of the tumours. READ MORE

5. 3. How tumour cells hijack apical extrusion and how they can be targeted

   Author : Weiyingqi Cui; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Tissue development and cell behavior are influenced not only by chemical signals but also by physical ones. The responses of cells to mechanical forces can range from the immediate adjustment of cell morphology and motility to long-term genome reorganisation and cell fate changes. READ MORE