Search for dissertations about: "BRCA1 and BRCA2"

Showing result 11 - 15 of 36 swedish dissertations containing the words BRCA1 and BRCA2.

  2. 11. Breast cancer in young women. Aspects of heredity and contralateral disease

    Author : Annelie Augustinsson; LUCC: Lunds universitets cancercentrum; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Early-onset; Genetic counseling; Genetic testing; BRCA1 and BRCA2; Contralateral breast cancer; Breast cancer; Early-onset; Genetic counseling; Genetic testing; BRCA1 and BRCA2; Contralateral breast cancer;

    Abstract : Breast cancer is the most commonly diagnosed cancer among women in Sweden, as well as worldwide. In Sweden, 8,288 women were diagnosed with invasive breast cancer in 2019, out of whom approximately 1.5% were younger than 35 years of age. READ MORE

  4. 12. Genetic and Epigenetic Characterisation of Breast Tumours

    Author : Karolina Holm; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; PIK3CA; PTEN; PI3K pathway; CCND1; microarrays; molecular subtypes; DNA methylation; EZH2; H3K27me3; PRC2; histone modification;

    Abstract : Breast tumours harbour a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. READ MORE

  5. 13. Genetic characterization of malignant melanoma and breast cancer

    Author : Göran B Jönsson; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; microarray; inherited breast cancer; Melanoma; linkage analysis; cancer; Cytologi; cancerology; onkologi;

    Abstract : Malignant melanoma and breast cancer are common malignant diseases characterized by considerable heterogeneity with respect to genetics, histopathology, biology and clinical course. In breast cancer, two major susceptibility genes have been identified, BRCA1 and BRCA2, which account for a significant proportion of high-risk breast cancer families. READ MORE

  6. 14. Treatment of BRCA1/2-associated breast cancer and identification of mutation carriers among breast cancer patients

    Author : Martin Nilsson; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The general aim of the research presented in this thesis was to contribute to the understanding of how breast cancer patients with germline BRCA1/2 mutations should be treated medically and surgically, and furthermore, to characterize the limitations and strengths of different procedures for BRCA testing. In Paper I, the long-term prognosis was assessed in a cohort of early-onset breast cancer patients (n = 221). READ MORE

  7. 15. Hereditary breast/ovarian cancer : implementation of BRCA1 and BRCA2 testing

    Author : Brita Arver; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer is the most common malignancy among women in the western world. Most cases are sporadic but in 5 to 10 % an inherited genetic mutation is the main cause of the disease. READ MORE