Search for dissertations about: "BRCA1 and BRCA2"
Showing result 16 - 20 of 36 swedish dissertations containing the words BRCA1 and BRCA2.
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16. Nucleic Acids as Drug Targets - Influence of Platinum Complexes on Duplex Stability and Binding Kinetics
Abstract : Gaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. READ MORE
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17. Cytogenetic studies of primary and metastatic breast cancer
Abstract : A series of primary and metastatic breast carcinomas obtained from female and male patients were cytogenetically analysed. Trisomy 12 was identified as a recurrent and sometimes early event in breast carcinogenesis. READ MORE
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18. Hereditary breast and ovarian cancer in western Sweden with a special focus on BRCA1 3171ins5 mutation
Abstract : Aims: To describe the phenotype and geographic distribution of the western Swedish founder mutation BRCA1 3171ins5, evaluate the reliability of mutation analysis of this mutation on archival material, analyse the haplotype for founder effects in families with BRCA1 3171ins5 mutation, estimate the age of this mutation and evaluate whether the occurrence of both breast and ovarian cancers in the same women may be a marker of a BRCA gene mutation. Materials and methods: The first study was based on 16 families with BRCA1 3171ins5 mutation and the second study was based on 18 families with the same mutation. READ MORE
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19. Family history and breast cancer susceptibility : clinical and molecular studies
Abstract : Apart from gender, family history is the most important risk factor for breast cancer. In 5-10 % of the cases there is a family history pattern of an autosomal dominant disease and there is also a familial clustering of breast cancer associated with a more modest increased risk of the disease. READ MORE
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20. Precision medicine of ovarian cancer for adults and children : molecular, hereditary and clinical aspects
Abstract : Ovarian cancer was 2018 ranked as the eighth most common cancer diagnosis and cause of death in women. Of these, the most common histological type is high-grade serous carcinoma. READ MORE