Search for dissertations about: "BRCA1 and BRCA2"

Showing result 26 - 30 of 36 swedish dissertations containing the words BRCA1 and BRCA2.

  2. 26. DNA repair pathways and the effect of radiotherapy in breast cancer

    Author : Karin Söderlund Leifler; Marie Askmalm Stenmark; Olle Stål; Bo Stenerlöw; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : A large proportion of breast cancer patients are treated with radiotherapy. Ionising radiation induces different DNA damages, of which double-strand breaks are the most severe. They are mainly repaired by homologous recombination or non-homologous end-joining. Different protein complexes have central roles in these repair processes. READ MORE

  4. 27. Molecular characterisation and prophylactic treatment strategies among women with benign gynecological disorders

    Author : Sakthivignesh Ponandai Srinivasan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Female reproduction is controlled by hormones in a timed and well-coordinated manner by the hypothalamus- pituitary - ovarian axis. In response to the ovarian hormones such as estrogen, and progesterone, endometrium, the inner lining of the uterus, undergoes repeated cycles of tissue growth, differentiation, tissue shedding and remodelling. READ MORE

  5. 28. Molecular studies in breast cancer susceptibility genes

    Author : Jindong Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : familial breast cancer; breast cancer susceptibility gene; BRCA1; BRCA2; ATM; TP53; PTEN MMAC1; STK11 LKB1; gene mutation; mutation screening; LOH;

    Abstract : Breast cancer is the most common malignancy among women, with a cumulative risk of approximately 12% by the age of 85. Of the breast cancer cases, 5-10% are hereditary. READ MORE

  6. 29. Molecular genetic analysis of human breast cancer

    Author : Catherine M Phelan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer accounts for approximately 20% of all female malignancies with hereditary breast cancer being implicated in 5-10% of these cases. Two highly penetrant hereditary breast cancer genes are known; BRCA1 (17q) and BRCA2 (13q), which also confer an increased risk of cancer at other sites. READ MORE

  7. 30. Landscaping the cell surface proteome of breast cancer : Following pathways through organelles to the plasma membrane

    Author : Emila Kurbasic; Institutionen för immunteknologi; []
    Keywords : Breast cancer; Proteomics;

    Abstract : Breast cancer is one of the most common cancers in women. It is most commonly treated by the surgical removal of the tumour in combination with (neo)-adjuvant therapy (hormone, chemo- or radio- therapy before or after surgery). READ MORE