Search for dissertations about: "BRCA1"

Showing result 21 - 25 of 57 swedish dissertations containing the word BRCA1.

  2. 21. DNA repair by HDR in experimental tumorigenesis

    Author : Ulrica Westermark; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this thesis was to further understand how defects in the homology-directed repair (HDR) pathway affect tumor formation and development. To study proteins involved in HDR is challenging since most of its members are required for cell viability. READ MORE

  4. 22. Genetic studies in familial breast cancer

    Author : Moraima Zelada Hedman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This study focuses on familial breast cancer, where some alteration is supposed to be inherited and predispose the individuals to breast cancer. Even when the majority of breast cancer cases are sporadic, a familial breast cancer study might light on over certain genes involved in the etiology of the disease. READ MORE

  5. 23. Genetic characterization of malignant melanoma and breast cancer

    Author : Göran B Jönsson; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; microarray; inherited breast cancer; Melanoma; linkage analysis; cancer; Cytologi; cancerology; onkologi;

    Abstract : Malignant melanoma and breast cancer are common malignant diseases characterized by considerable heterogeneity with respect to genetics, histopathology, biology and clinical course. In breast cancer, two major susceptibility genes have been identified, BRCA1 and BRCA2, which account for a significant proportion of high-risk breast cancer families. READ MORE

  6. 24. Molecular genetic analysis of human breast cancer

    Author : Catherine M Phelan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer accounts for approximately 20% of all female malignancies with hereditary breast cancer being implicated in 5-10% of these cases. Two highly penetrant hereditary breast cancer genes are known; BRCA1 (17q) and BRCA2 (13q), which also confer an increased risk of cancer at other sites. READ MORE

  7. 25. Genetic predisposition for cancer : genes and genetic counseling

    Author : Johanna Rantala; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer accounts for one third of all female cancer cases worldwide. A hereditary component accounts for 10-15% of all breast and ovarian cancer cases. The overall aim of this thesis is to evaluate and improve genetic diagnostic and genetic counseling in hereditary cancer patients. READ MORE