Search for dissertations about: "BRCA1"

Showing result 26 - 30 of 57 swedish dissertations containing the word BRCA1.

  2. 26. Family history and breast cancer susceptibility : clinical and molecular studies

    Author : Sara Margolin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : breast cancer; family history; sporadic; familial; BR CA 1; CHEK2; polymorphism; association; estrogen receptor alpha; estrogen receptor beta;

    Abstract : Apart from gender, family history is the most important risk factor for breast cancer. In 5-10 % of the cases there is a family history pattern of an autosomal dominant disease and there is also a familial clustering of breast cancer associated with a more modest increased risk of the disease. READ MORE

  4. 27. Histologic characterization of stem cells in mammary epithelium and stroma

    Author : Björn Isfoss; Tumörmikromiljö; []
    Keywords : ;

    Abstract : It is unknown whether native cells in benign breast tissue mediate risk of cancer.We therefore aimed to identify cell types in benign human mammary tissueimmunohistologically using markers of stemness and differentiation, and toinvestigate their possible associations with clinical risk factors for breast cancer. READ MORE

  5. 28. Exercise and regulation of metabolic function in human skeletal muscle : with special reference to PGC-1α and the mitochondria

    Author : Eva-karin Gidlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Regular physical activity is highly associated with many health benefits and regular exercise training is used in the prevention and treatment of a large number of disease conditions, including type 2 diabetes, cardiovascular disease and cancer. One of the key adaptations to regular exercise training is mitochondrial biogenesis and improved oxidative capacity, particularly in skeletal muscle tissue. READ MORE

  6. 29. Molecular characterisation and prophylactic treatment strategies among women with benign gynecological disorders

    Author : Sakthivignesh Ponandai Srinivasan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Female reproduction is controlled by hormones in a timed and well-coordinated manner by the hypothalamus- pituitary - ovarian axis. In response to the ovarian hormones such as estrogen, and progesterone, endometrium, the inner lining of the uterus, undergoes repeated cycles of tissue growth, differentiation, tissue shedding and remodelling. READ MORE

  7. 30. Molecular mechanisms of antibody diversification in human B-cells

    Author : Andrea Björkman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : B-cells undergo several somatic rearrangement/mutational processes during development to diversify their immunoglobulin (Ig) receptors. First, the antigen binding Ig variable (V) region is assembled through V(D)J recombination. READ MORE