Search for dissertations about: "Bilayer disk"

Found 5 swedish dissertations containing the words Bilayer disk.

  1. 1. Nanosized Bilayer Disks as Model Membranes for Interaction Studies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Lundquist; Uppsala universitet.; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Disk; disc; lipid bilayer; PEG-lipid; model membrane; interaction; partitioning; drug; liposome; cryo-TEM; neutron scattering; capillary electrophoresis; immobilization; biosensor; membrane protein; melittin; NATURAL SCIENCES Chemistry; NATURVETENSKAP Kemi;

    Abstract : PEG-lipid stabilized bilayer disks have been found in lipid mixtures containing polyethylene glycol (PEG)-lipids where the combination of a high bending rigidity and low PEG-lipid/lipid miscibility favours disk formation. The disks are planar and circular in shape and their long-term stability is excellent. READ MORE

  2. 2. Partitioning of Drugs and Lignin Precursor Models into Artificial Membranes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Elisabet Boija; Uppsala universitet.; [2006]
    Keywords : Biochemistry; Bilayer disk; Capillary electrophoresis; Detergent; Drug; Electrostatic interaction; Hydrophobic interaction; Immobilized liposome chromatography; Lignin; Lignin precursor model; Liposome; Membrane model; Octanol water partitioning; Partitioning; Phospholipid; Phospholipid bilayer; Sterol; Biokemi;

    Abstract : The main aim of this thesis was to characterize membrane-solute interactions using artificial membranes in immobilized liposome chromatography or capillary electrophoresis. The partitioning of a solute into a cell membrane is an essential step in diffusion across the membrane. READ MORE

  3. 3. Drug Partitioning into Natural and Artificial Membranes Data Applicable in Predictions of Drug Absorption

    University dissertation from Uppsala : Institutionen för naturvetenskaplig biokemi

    Author : Caroline Engvall; Uppsala universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Bilayer disk; Cholesterol; Drug partitioning; Drugs; Electrostatic effects; Immobilized liposome chromatography; Liposome; Membrane protein; Model membrane; Oligonucleotide-liposome complex; Phospholipid; Phospholipid bilayer; Proteoliposome; Surfactant; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Abstract : When drug molecules are passively absorbed through the cell membrane in the small intestine, the first key step is partitioning of the drug into the membrane. Partition data can therefore be used to predict drug absorption. READ MORE

  4. 4. Development and Evaluation of Lipodisks Intended for Use as Biomimetic Membranes and Drug Carriers

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Malin Morin Zetterberg; Uppsala universitet.; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; model membranes; drug delivery; drug partitioning; antimicrobial peptides; nanocarriers; cryo-TEM; polymer-stabilized bilayer disks; Chemistry with specialization in Physical Chemistry; Kemi med inriktning mot fysikalisk kemi;

    Abstract : Polyethylene glycol-stabilized lipodisks have emerged as a novel type of lipid-based nanoparticles with high potential as both drug carriers and biomimetic membranes. In this thesis we assess both of these applications, and show how the properties of the lipodisks can be further developed and optimized. READ MORE

  5. 5. Physico-Chemical Investigations of, and Characterization of Model Membranes for, Lipid-Peptide Interactions

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Per Wessman; Uppsala universitet.; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES Chemistry Physical chemistry; NATURVETENSKAP Kemi Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

    Abstract : The main focus of this thesis is on the effects caused by α-helical peptides on liposome structure, the impact of cholesterol on the peptide-membrane interactions, and the effect of aggregate curvature on the peptide affinity. Results of the studies show that the membrane destabilizing effect of the cationic α-helical peptide melittin is modulated by cholesterol. READ MORE