Search for dissertations about: "Bilayer disk"
Showing result 1 - 5 of 6 swedish dissertations containing the words Bilayer disk.
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1. Nanosized Bilayer Disks as Model Membranes for Interaction Studies
Abstract : PEG-lipid stabilized bilayer disks have been found in lipid mixtures containing polyethylene glycol (PEG)-lipids where the combination of a high bending rigidity and low PEG-lipid/lipid miscibility favours disk formation. The disks are planar and circular in shape and their long-term stability is excellent. READ MORE
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2. Partitioning of Drugs and Lignin Precursor Models into Artificial Membranes
Abstract : The main aim of this thesis was to characterize membrane-solute interactions using artificial membranes in immobilized liposome chromatography or capillary electrophoresis. The partitioning of a solute into a cell membrane is an essential step in diffusion across the membrane. READ MORE
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3. Drug Partitioning into Natural and Artificial Membranes : Data Applicable in Predictions of Drug Absorption
Abstract : When drug molecules are passively absorbed through the cell membrane in the small intestine, the first key step is partitioning of the drug into the membrane. Partition data can therefore be used to predict drug absorption. READ MORE
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4. Development and Evaluation of Lipodisks Intended for Use as Biomimetic Membranes and Drug Carriers
Abstract : Polyethylene glycol-stabilized lipodisks have emerged as a novel type of lipid-based nanoparticles with high potential as both drug carriers and biomimetic membranes. In this thesis we assess both of these applications, and show how the properties of the lipodisks can be further developed and optimized. READ MORE
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5. Physico-Chemical Investigations of, and Characterization of Model Membranes for, Lipid-Peptide Interactions
Abstract : The main focus of this thesis is on the effects caused by α-helical peptides on liposome structure, the impact of cholesterol on the peptide-membrane interactions, and the effect of aggregate curvature on the peptide affinity. Results of the studies show that the membrane destabilizing effect of the cationic α-helical peptide melittin is modulated by cholesterol. READ MORE