Search for dissertations about: "Bile acid transporter"

Showing result 1 - 5 of 9 swedish dissertations containing the words Bile acid transporter.

  2. 1. Studies on the hormonal regulation of bile acid synthesis

    Author : Thomas Lundåsen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The maintenance of a normal turnover of cholesterol is of vital importance, and disturbances of cholesterol metabolism may result in several important disease conditions. The major route for the elimination of cholesterol from the body is by hepatic secretion of cholesterol and bile acids (BAs) into the bile for subsequent fecal excretion. READ MORE

  4. 2. Modulation of bile acid and cholesterol metabolism in health and disease

    Author : Cecilia Gälman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Bile acids - cholesterol - gallstone - cholic acid - cholestyramine - high performance liquid chromatography - species - C4 - 7alpha-hydroxy-4-cholesten-3 -one cholesterol 7alpha-hydroxylase - lipoproteins - hyperlipidemia - statins - resins - diurnal variation - ASBT - 3-hydroxy-3-methylglutaryl coenzyme A;

    Abstract : An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis is a strategy to reduce plasma cholesterol. This partly occurs due to an induction of hepatic LDL receptors. READ MORE

  5. 3. Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease

    Author : Samer Al-Dury; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinska sjukdomar; Gastroenterologi och hepatologi; FXR; IBAT; Gallsyror; Obesitas; Gallstenar;

    Abstract : Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic modality for a range of liver and metabolic diseases. READ MORE

  6. 4. Spices in the postprandial metabolic regulation of healthy humans : An integrated physiological and omics approach

    Author : Yoghatama Cindya Zanzer; Avdelningen för livsmedel och läkemedel; []
    Keywords : Spices; Postprandial; Glycemia; Lipemia; Appetite regulation; Metabolic endotoxemia; Bile acids; Transcriptomics; Nutrigenomics;

    Abstract : Metabolic syndrome (MetS) is a consequence of obesity and defined as cluster of at least three out of five criteria covering insulin resistance/glucose intolerance, abdominal obesity, hypertension, low HDL-c and elevated TG levels. Imbalance between energy intake and expenditure is known to alter normal physiological function in many aspects, and leads to obesity, which in the long run may turn into type 2 diabetes (T2D) and ultimately cardiovascular disease (CVD). READ MORE

  7. 5. Digestion and absorption of galactolipids

    Author : Lena Ohlsson; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastro-enterology; Pancreatic lipase related proteins.; Pancreatic lipase; Monogalactosyldiglyceride; Lipolytic enzymes; Galactolipids; Essential fatty acids; Digestion; Digalactosyldiglyceride; Colipase; Chylomicron; Bile salt stimulated lipase; Carboxyl ester lipase; Gastroenterologi; Proteins; enzymology; Proteiner; enzymologi; Lipids; steroids; membranes; Lipider; steroider; mebran;

    Abstract : Galactolipids: digalactosyldiglyceride (DGalDG), monogalactosyldiglyceride (MGalDG) and sulfoquinovosyldiglyceride (SQDG) are the major lipid components in thylakoid membranes of chloroplasts i.e. the site of photosynthesis in plants. READ MORE