Search for dissertations about: "Biotechnology"
Showing result 16 - 20 of 1667 swedish dissertations containing the word Biotechnology.
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16. Exploring genetic heterogeneity in cancer using high-throughput DNA and RNA sequencing
Abstract : High-throughput sequencing (HTS) technology has revolutionised the biomedical sciences, where it is used to analyse the genetic makeup and gene expression patterns of both primary patient tissue samples and models cultivated in vitro. This makes it especially useful for research on cancer, a disease that is characterised by its deadliness and genetic heterogeneity. READ MORE
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17. Development of novel affinity enrichment strategies for clinical applications using selected reaction monitoring
Abstract : Proteins are key components of any living organism and an essential part of life itself. They can provide cells with structure and perform life-sustaining intracellular reactions. As organisms grow more complex, this task expands even further. READ MORE
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18. Gliadin-Blocking Peptides In vitro assessment of their potential to alleviate celiac disease development
Abstract : This thesis work aimed to investigate the potential of synthetic peptides as agents to block wheat prolamins (gliadins) that trigger the development of symptoms in celiac disease. The first step of this investigation included selection and synthesis of peptides with high affinity to gliadins and assessment of the potential of these so-called blocking peptides to limit gliadin reactivity in vitro. READ MORE
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19. Novel methods for improving rapid paper-based protein assays with gold nanoparticle detection
Abstract : This thesis describes methods for improving sensitivity in rapid singleplex and multiplex microarray assays. The assays utilize the optical characteristics of colloidal gold nanoparticles for the colorimetric detection of proteins.Multiplexed detection in sandwich immunoassays is limited by cross-reactivity between different detection antibodies. READ MORE
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20. Generation and engineering of ABD-derived affinity proteins for clinical applications
Abstract : Proteins that specifically recognize and bind to other molecules or structures are important tools in industrial and medical applications. Binding proteins engineered from small stable scaffold proteins have been utilized for several purposes due to their favorable biophysical properties, tolerance to mutagenesis, efficient tissue penetration and ease of production. READ MORE