Search for dissertations about: "C Karlsson"

Showing result 1 - 5 of 137 swedish dissertations containing the words C Karlsson.

  2. 1. Viral dynamics and evolution following primary HIV-1 infection

    Author : Annika C Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; primary infection; diversity; divergence; env; gag; pol; viral load; RNA; DNA; resting CD4 T-lyrnphocytes; antiretroviral resistance; founder virus; latency; PCR; cloning; sequencing;

    Abstract : The knowledge of the early events during primary HIV-1 infection (PER) is of great importance for the understanding of the pathogenesis of HIV-1. A major problem in studies on PHI is the limited amount of data accessible from the early time-points. READ MORE

  4. 2. Genetic characterization to dissect the phenotypic complexity of autoimmunity

    Author : Jenny C Karlsson; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; epistasis; EAE; autoimmunity; Immunology; CIA; QTL;

    Abstract : Autoimmune diseases are dependent on multiple genes and unknown environmental factors. Great efforts in the identification of genes conferring susceptibility to autoimmune diseases like Rheumatoid Arthritis (RA) and Multiple Sclerosis (MS) have recently been rewarding. READ MORE

  5. 3. Biomarkers for colon cancer : applications in human and rat studies

    Author : Pernilla C. Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Colon cancer biomarkers; faecal water; polyethylene glycol; synbiotics; COX-2 inhibitors;

    Abstract : Colon cancer is one of the major causes of cancer in industrialized countries, and it is caused by a combination of hereditary, environmental and dietary factors and lack of physical activity. Of these factors, diet is one of the most important. READ MORE

  6. 4. P-glycoprotein and chiral antidepressant drugs : Pharmacokinetic, pharmacogenetic and toxicological aspects

    Author : Louise Karlsson; Fredrik C. Kugelberg; Finn Bengtsson; Johan Ahlner; Aleksander A. Mathé; Linköpings universitet; []
    Keywords : ;

    Abstract : The blood-brain barrier (BBB) is formed by the capillary endothelial cells, joined together by tight junctions, with transporter proteins. BBB acts to regulate the brain concentrations of substances including many drugs. READ MORE

  7. 5. Methodological Studies on Models and Methods for Mixed-Effects Categorical Data Analysis

    Author : Maria C. Kjellsson; Mats O. Karlsson; Siv Jönsson; Gordon Graham; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacodynamics; Categorical data; Markov model; Modelling; NONMEM; NLMIXED; Laplace; Gaussian quadrature; Back-Step Method; Proportional odds model; Differential odds model;

    Abstract : Effects of drugs are in clinical trials often measured on categorical scales. These measurements are increasingly being analyzed using mixed-effects logistic regression. However, the experience with such analyzes is limited and only a few models are used. READ MORE