Search for dissertations about: "CD40L"

Showing result 1 - 5 of 37 swedish dissertations containing the word CD40L.

  2. 1. CD40L Gene Therapy for Solid Tumors

    Author : Lina Liljenfeldt; Thomas Tötterman; Angelica Loskog; Sara Mangsbo; Evren Alici; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40L; adenovirus; tumor immunology; tumor microenvironment; immunotherapy; local immunotherapy; antigen presentation; Immunologi; Immunology;

    Abstract : Adenoviral CD40L gene therapy (AdCD40L) is a strong inducer of anti-tumor immune responses via its activation of dendritic cells (DCs). Activated DCs can in turn activate T cells, which are key players in an efficient anti-tumor response.This thesis includes three papers that focus on different aspects of AdCD40L gene therapy. READ MORE

  4. 2. Intratumoral CD40 stimulating therapy in patients with advanced cancer

    Author : Sandra Irenaeus; Gustav Ullenhag; Angelica S. Loskog; Poulam Patel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40; CD40L; immunotherapy; early clinical studies; advanced cancer; intratumoral administration; Medicinsk vetenskap; Medical Science; Oncology; Onkologi;

    Abstract : CD40-CD40L interaction activates DCs to become highly efficient APCs and skews the adaptive immune response towards a Th I phenotype driving cytotoxic T cells, M1 macrophages and natural killer cells. Furthermore, engagement of CD40L to CD40 positive cancer cells can have direct anti-proliferative effects, induce apoptosis and increase expression of MHC and other co-stimulatory molecules, thereby enhancing cancer cell recognition. READ MORE

  5. 3. Preclinical evaluation of immunostimulatory gene therapy for pancreatic cancer

    Author : Emma Eriksson; Angelica Loskog; Tanja de Gruijl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic cancer; immunotherapy; oncolytic viruses; adenoviruses; CD40L; 4-1BBL; IL-6; tumor microenvironment; Klinisk immunologi; Clinical Immunology;

    Abstract : Pancreatic cancer is characterized by its desmoplastic tumor microenvironment and the infiltration of immunosuppressive cells. It is a devastating disease where most patients are diagnosed at a late stage and the treatment options are few. The development of new treatments is surly needed. READ MORE

  6. 4. Regulation of lymphocyte activation and death

    Author : Hanna Lindgren; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; N-substituted benzamides; apoptosis; NF-kB; NFAT; T cells; CD40L; serology; transplantation; Immunologi; serologi;

    Abstract : T lymohocytes (T cells) and B lymphocytes (B cells) are important effector cells of the adaptive immune system. In response to infections, B cells are activated and produce antibodies against specific antigens. READ MORE

  7. 5. Immunogene Therapy of Bladder Carcinoma : A Preclinical Study

    Author : Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Immunotherapy; Gene therapy; Immunogene therapy; CD40L; Bladder carcinoma; Onkologi; Oncology; Onkologi; Klinisk immunologi; Clinical Immunology;

    Abstract : This thesis comprises studies on murine and human models of bladder carcinoma with the aim to develop novel immunogene therapies. On the basis of the results presented in this thesis, a clinical trial is underway. The potential of activating the immune system to combat cancer has long intrigued immunologists. READ MORE