Search for dissertations about: "CD52"

Found 4 swedish dissertations containing the word CD52.

  2. 1. Targeted CD52 therapy in lymphoid malignancies : a clinical and immunological study

    Author : Jeanette Lundin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CD52; alemtuzumab; Campath; monoclonal antibodies; chronic lymphocytic leukemia; non-Hodgkin s lymphoma; mycosis fungoides; immune suppression;

    Abstract : There is a great need for developing new treatment alternatives in low grade non Hodgkin's lymphoma (NHL) including chronic lymphocytic leukemia (CLL). The CD52 antigen, which is expressed on almost all lymphoid malignancies, can be utilized as a target for CD52-directed monoclonal antibody therapy (alemtuzumab, Campath-1 H). READ MORE

  4. 2. Development of Transient Flamelet Library Based Combustion Models

    Author : Harry Lehtiniemi; Förbränningsfysik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; auto-ignition; conditional moment closure; Tabulated chemistry; flamelet; spray; non-premixed combustion; Fysicumarkivet A:2012:Lehtiniemi;

    Abstract : Three different methods for Reynolds-averaged Navier-Stokes computational fluid dynamics modeling of non-premixed ignition and combustion using tabulated chemistry have been developed. All methods make use of flamelet libraries, where the flamelet auto-ignition process is parameterized using a progress variable. READ MORE

  5. 3. Targets for immune mediated killing of tumor cells and T cell functions in B-CLL

    Author : Eva D Rossmann; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Chronic lymphocytic leukemia; apoptosis; monoclonal antibody therapy; quantitative flow cytometry; cytokines; T cell dysfunctions;

    Abstract : There is a great need for developing and improving treatment alternatives in B-cell chronic lymphocytic leukemia (B-CLL). New therapeutical approaches based on the manipulation of the immune system enable establishment of enhanced control over the malignant clone. READ MORE

  6. 4. T cells in patients with B-cell chronic lymphocytic leukemia (B-CLL) and multiple myeloma (MM) : an immunological study

    Author : Shahryar Kiaii; Karolinska Institutet; Karolinska Institutet; []
    Keywords : T cell; B-cell Chronic Lymphocytic Leukemia ; Multiple Myeloma ; signaling; gene expression;

    Abstract : There are several lines of evidence that T cells in patients with Multiple Myeloma (MM) and B-cell Chronic Lymphocytic Leukemia (B-CLL) are phenotypically aberrant. The overall aim of this thesis was to study T cells with a focus on TCR-signaling pathways in these two B-cell malignancies. The role of T-cells in B-CLL etiology was also examined. READ MORE