Search for dissertations about: "CD8 analysis"

Showing result 1 - 5 of 124 swedish dissertations containing the words CD8 analysis.

  2. 1. The use of immunological biomarkers to improve individualization of postoperative radiotherapy in breast cancer

    Author : Axel Stenmark Tullberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor-infiltrating lymphocytes; CD8; FOXP3; Radiotherapy; Breast cancer;

    Abstract : Radiotherapy (RT) forms the cornerstone of most curative breast cancer treatment due to its well-established risk-reducing effect on local recurrences at the population level. However, there is heterogeneity regarding treatment benefits at the individual level, and research currently aims to better tailor treatment decisions based on tumor biology. READ MORE

  4. 2. HIV-1 evolution, disease progression and molecular epidemiology of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals in Guinea-Bissau

    Author : Joakim Esbjörnsson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; HIV-2; Guinea-Bissau; subtype; disease progression; evolution; coreceptor tropism; CXCR4; gp120; V1-V3; CD4%; CD8%; soluble immune markers;

    Abstract : The two genetically related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 infected individuals. READ MORE

  5. 3. The dimensions of human and murine CD8 T lymphocyte diversity

    Author : Anthonie Johan Zwijnenburg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The adaptive immune system generates and maintains a pool of CD8+ T cells with an almost limitless specificity with the purpose of maintaining homeostasis. Upon antigen encounter, CD8+ T cells undergo functional diversification and give rise to daughter cells. READ MORE

  6. 4. Positional identification and functional analysis of genes regulating autoimmune arthritis

    Author : Anthony Chun Yeung Yau; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The major histocompatibility complex (MHC) is the most gene-dense and polymorphic region in the human genome with strong associations to many autoimmune disorders, including rheumatoid arthritis (RA). However, even the genetic association between MHC and RA was known more than 40 years ago, we still have not fully explained the functional roles of the MHC genes and identified the underlying specific polymorphisms. READ MORE

  7. 5. Spatial immune analyses in clinical cancer tissue

    Author : Max Backman; Patrick Micke; Fredrik Pontén; Johan Botling; Kurt Schalper; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immune landscape; non-small cell lung cancer; immune cells; multiplex immunofluorescence; spatial analysis; Medicinsk vetenskap; Medical Science;

    Abstract : Cancer is a leading cause of premature death and lung cancer is the deadliest cancer type, with non-small cell lung cancer (NSCLC) representing 85% of lung cancer cases. Despite promising development in cancer treatment in recent decades, overall prognosis is poor. READ MORE