Search for dissertations about: "CDK4 CDK6 Regulation"
Found 2 swedish dissertations containing the words CDK4 CDK6 Regulation.
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1. The cell cycle regulators p15, p16, p18 and p19 : functions and regulation during normal cell cycle and in multistep carcinogenesis
Abstract : The tumor suppressor protein p16INK4a and its family members p15INK4b, p18INK4c and p19INK4d (the INK4 proteins) inhibit the cyclin-dependent kinases CDK4 and CDK6, which are key regulators of the retinoblastoma protein (pRb). pRb guars entry into the S phase of the mammalian cell division cycle (the cell cycle), a process evolved to ensure balanced cell proliferation. READ MORE
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2. Ribosomal Proteins in Diamond-Blackfan Anemia : Insights into Failure of Ribosome Function
Abstract : Diamond-Blackfan anemia (DBA) is a severe congenital anemia characterized by a defect in red blood cell production. The disease is associated with growth retardation, malformations, a predisposition for malignant disease and heterozygous mutations in either of the ribosomal protein (RP) genes RPS7, RPS17, RPS19, RPS24, RPL5, RPL11 and RPL35a. READ MORE