Search for dissertations about: "CFTR"

Showing result 1 - 5 of 29 swedish dissertations containing the word CFTR.

2. 1. CFTR in pancreatic islets

   Author : Anna Edlund; Diabetes - öcellsexocytos; []
   Keywords : CFTR; CF; CFRD; Cystic fibrosis; Cystisk fibros; Diabetes; Insulin; Beta cell; Glukagon; Glucagon; Alpha cell; Alfa-cell; Anoctamin; ANO1; ANO;

   Abstract : AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. READ MORE

4. 2. Advances in Pharmacological Treatment of Cystic Fibrosis

   Author : Igor Oliynyk; Godfried M. Roomans; Marie Johannesson; Hugo R. de Jonge; Örebro universitet; []
   Keywords : Cystic fibrosis; CFTR; chloride transport; N-acetylcysteine; NO-donors; duramycin; intracellular calcium; azithromycin; MEDICINE; MEDICIN; Medicin; Medicine;

   Abstract : Cystic fibrosis (CF) is an inborn, hereditary disease, due to mutations in the gene for a cAMP-activated chloride (Cl-) channel, the cystic fibrosis transmembrane conductance regulator (CFTR). As a result of impaired ion and water transport,the airway mucus is abnormally viscous, which leads to bacterial colonization. READ MORE

5. 3. Functional Aspects of Epithelia in Cystic Fibrosis and Asthma

   Author : Zhanna Servetnyk; Godfried Roomans; Michael Wilschansky; Uppsala universitet; []
   Keywords : Cell biology; cystic fibrosis; CFTR; chloride transport; airway epithelium; sweat gland; asthma; corticosteroids; montelukast; Cellbiologi;

   Abstract : The cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP activated chloride channel in the apical membrane of epithelial cells, is defective in patients with cystic fibrosis (CF). Research efforts are focused on chloride channel function in order to find a cure for the disease. READ MORE

6. 4. Towards Pharmacological Treatment of Cystic Fibrosis

   Author : Charlotte Andersson; Aleksander Edelman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; cystic fibrosis; airway epithelium; genotype; CFTR; chloride transport; genistein; phenotype; phenylbutyrate; S-nitrosoglutathione; Cellbiologi; Cell biology; Cellbiologi; entomologi; Entomology;

   Abstract : S-nitrosogluthatione is an endogenous substance, present at decreased levels in the lungs of CF patients and was recently found to induce mature CFTR in airway epithelial CF cell lines. We show that S-nitrosoglutathione in physiological concentrations increases the presence of ΔF508 CFTR in the cell membrane and induces cAMP dependent chloride transport in cystic fibrosis airway epithelial cells. READ MORE

7. 5. Chloride transport and inflammation in cystic fibrosis airways

   Author : Georgia Varelogianni; Godfried Roomans; Marie Johannesson; Ólafur Baldersson; Örebro universitet; []
   Keywords : Cystic fibrosis; CFTR; chloride efflux; N-acetylcysteine; ambroxol; duramycin; Nod-like receptors; cytokines; Medicin; Medicine;

   Abstract : Cystic fibrosis (CF) is one of the most common lethal, autosomal recessive inherited diseases among Caucasians. It is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel activated by cyclic AMP. READ MORE