Search for dissertations about: "CGRP-receptors"

Found 4 swedish dissertations containing the word CGRP-receptors.

  2. 1. Sensory neuropeptides and nitric oxide in nasal vascular regulation

    Author : Johan Rinder; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Sensory nerves; neuropeptides; nasal mucosa; nitric oxide; vascular regulation; acoustic rhinometry; NK1-receptors; CGRP-receptors; vanilloid receptors; capsaicin; lactic acid; exercise; a-adrenoceptor agonists; pig; human.;

    Abstract : The role of sensory neuropeptides and nitric oxide in vascular regulation was investigated in the pig nasal mucosa in vivo using arterial blood flow measurements and acoustic rhinometry for analysis of capacitance function. Moreover, the effects of heavy physical exercise, a-adrenoceptor agonists, nitric oxide synthase (NOS) inhibition, L-arginine, nitric oxide (NO) gas, histamine and capsaicin on nasal cavity NO levels and nasal cavity volume, were investigated in healthy subjects. READ MORE

  4. 2. A study on the vascular effects of prostaglandin F2α[ and latanaprost in the eye with special reference to the surface hyperaemia after topical administration

    Author : Maria Astin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Prostaglandin F2a; Prostaglandin F2a-isopropyl ester; latanoprost; latanoprost acid; ocularhyperaemia; blood flow; sensory nerves; veins; arteries; nitric oxide; substance P; CGRP; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmacognosy; farmakognosi;

    Abstract : The ocular hypotensive effect of topically applied prostaglandins is usually accompanied byconjunctival hyperaemia and irritation. The purpose of the present study was to investigate thepharmacological mechanism of the ocular surface hyperaemia induced by topically appliedprostaglandins, particularly prostaglandin F2α (PGF2α) and its synthetic analogue latanoprost, aselective FP prostanoid receptor agonist. READ MORE

  5. 3. Neuronal mechanisms in tendon healing : effects of mobilization and immobilization

    Author : Daniel K-I Bring; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The incidence of tendon injuries is increasing. Tendon healing and modelling are frequently protracted, often leading to pain and impaired function so called overuse syndromes. Presumably, the sensory nervous system may contribute both to promotion of repair as well as to inhibition of healing and tissue modeling. READ MORE

  6. 4. Contribution of the sensory nervous system : an experimental study in the rat

    Author : Olle Löfgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : edema; hindpaw withdrawal latency HWL ; inflammation; microcirculation; scalding; sensory nervous system; sensory neuropeptide antagonists; sensory neuropeptides; thermal injury;

    Abstract : The pathophysiological background to burn induced inflammatory reactions is poorly understood and present therapy options are limited. A model of thermal injury was developed to enable investigations of the acute inflammatory reactions in the periphery as well as of the transmission of nociception at the spinal cord level. READ MORE