Search for dissertations about: "CILP"

Found 3 swedish dissertations containing the word CILP.

  2. 1. Identification and characterization of a novel cartilage gene product CILP, which is an early indicator of osteoarthritis

    Author : Pilar Lorenzo; Reumatologi och molekylär skelettbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscle system; Skeleton; matrix protein; NTPPHase; CILP; osteoarthritis; human cartilage; rheumatology locomotion; Skelett; muskelsystem; reumatologi;

    Abstract : The aim of this work was to study alterations in the matrix composition of human articular cartilage in different stages of osteoarthritis and to isolate and characterize one of the proteins that is altered in the osteoarthritic process. The metabolism of articular cartilage in different stages of osteoarthritis including early asymptomatic OA was monitored in a culture system of metabolically labeled cartilage explants. READ MORE

  4. 2. Proinflammatory and antigen-specific CD4+ T cells in rheumatoid arthritis

    Author : Jennifer Pieper; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease primarily affecting peripheral joints. In this thesis work we aimed to increase the knowledge about proinflammatory and antigen-specific CD4+ T cell subsets involved in RA pathogenesis and I also investigated the effect of T cell directed therapy (abatacept) on CD4+ T cell subsets. READ MORE

  5. 3. The T cell phenotype and receptor repertoire in different stages of rheumatoid arthritis : an immunological timeline

    Author : Sara Turcinov; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rheumatoid arthritis (RA) is a systemic autoimmune disease, characterized by symmetrical inflammation in hands and feet. Antibodies recognizing citrullinated protein (ACPA) and/or rheumatoid factor (RF) are found in most patients and associates with a worse prognosis. Genetic predisposition (i.e. READ MORE