Search for dissertations about: "CMS"

Showing result 1 - 5 of 26 swedish dissertations containing the word CMS.

  2. 1. Optimization of Colistin Dosage in the Treatment of Multiresistant Gram-negative Infections

    Author : Matti Karvanen; Otto Cars; Lena E Friberg; Vincent H Tam; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colistin; CMS; Pharmacology; Pharmacokinetics; PKPD; Antibiotics; Combination therapy; Pharmacometrics; Dosing regimens; Antibiotic resistance; Infectious Diseases; Infektionssjukdomar;

    Abstract : As multidrug resistance in Gram-negative bacilli increases, the old antibiotic colistin has rapidly gained attention as one of few last line treatment options in the form of colistin methanesulfonate (CMS), which is hydrolyzed to colistin both in vitro and in vivo. There is a dearth of knowledge on fundamental aspects of colistin, including pharmacokinetics and optimal dosing regimens. READ MORE

  4. 2. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection

    Author : Salim Bouchene; Mats O. Karlsson; Wilhelm Huisinga; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBPK model; endotoxin; colistin; WBPBPK-PD; CMS; inflammation; tissue distribution; Kp; predictions in tissue; interspecies scaling;

    Abstract : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. READ MORE

  5. 3. Development of Accurate Reduced Order Models in a Simulation Tool for Turbomachinery Aeromechanical Phenomena

    Author : Mauricio Gutierrez Salas; Björn Laumert; Paul Petrie-Repar; Damian Vogt; Carlos Martel; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; flutter; forced response; high cycle fatigue; reduced order models; ROM; craig-bampton; mistuning; tuned; mistuned; cyclic; noncyclic; craig-chang; free-interface. fixed-interface; subset nominal mode; SNM; CBMS; CCMS; CCC; CBC; FEM; CMS; modal; eigen; modeshapes; aeroelasticity; aeromechanical; tool; turbomachinery; turbine; compressor; AROMA; Energy Technology; Energiteknik;

    Abstract : Modern gas turbines are still vulnerable to vibrations when operated at certain speeds. This unstable environment can lead to high cycle fatigue (HCF) and damage several of the components inside the turbine. READ MORE

  6. 4. Load and risk based maintenance management of wind turbines

    Author : Pramod Bangalore; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; condition monitoring system CMS ; optimization; supervisory control and data acquisition SCADA ; maintenance planning; Artificial neural network ANN ; life cycle cost; maintenance management; maintenance strategy; wind energy.;

    Abstract : Wind power has proven to be an important source of renewable energy in the modern electric power systems. Low profit margins due to falling electricity prices and high maintenance costs, over the past few years, have led to a focus on research in the area of maintenance management of wind turbines. READ MORE

  7. 5. Load and Risk Based Maintenance Management of Wind Turbines

    Author : Pramod Bangalore; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; optimization; wind energy.; supervisory control and data acquisition SCADA ; condition monitoring system CMS ; Artificial neural networks ANN ; maintenance strategy; maintenance planning; maintenance management; life cycle cost;

    Abstract : The cost of maintenance is a considerable part of the total life cycle cost in wind turbines, especially for offshore applications. Research has shown that some critical components account for most of the downtime in the wind turbines. READ MORE