Search for dissertations about: "CX3CR1"

Showing result 1 - 5 of 16 swedish dissertations containing the word CX3CR1.

  2. 1. Phenotype and function of intestinal CD103+ dendritic cells

    Author : Elin Jaensson Gyllenbäck; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD103; dendritic cell; CX3CR1; small intestine; MLN; CCR9; Vitamin A; retinoic acid;

    Abstract : Mucosal tissues such as the intestine present an enormous surface area to the outside environment and are continually exposed to foreign antigens in food and microflora. Thus, the intestinal mucosa must must remain tolerant to these innocuous antigens while at same time be able to mount effective immune responses to pathogens. READ MORE

  4. 2. Finding synergies for cancer treatment : new ways to modulate DNA damage repair by CX3CR1 and PFKFB3 inhibition

    Author : Jemina Lehto; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The goal of targeted cancer therapy is to selectively kill cancer cells based on their molecular survival mechanisms. DNA repair is as a promising cancer target as many cancers have chronic replication stress and deficiencies in the DNA damage response. READ MORE

  5. 3. Emerging roles of PFKFB3 and CX3CR1 in the DNA damage response and their potential as therapeutic targets in cancer

    Author : Anna Huguet Ninou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Genomic instability in cancer is exploited therapeutically using DNA damaging therapies that cause irreparable lesions above the threshold of tolerable DNA damage levels. Nevertheless, toxic side effects on healthy tissues limit the therapeutic potential of such therapies. READ MORE

  6. 4. Chemokine receptor expression and function in experimental autoimmune neuroinflammation

    Author : Sana Eltayeb; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neuroinflammatory lesions in the central nervous system (CNS) are characterized by the presence of leukocytes, mainly monocytes/macrophages, derived from the systemic compartment. We believe CC inflammatory chemokine receptors (CkRs), CCR1, CCR2 and CCR5 are prerequisite for controlling the migration of monocytes/macrophages into inflammatory foci. READ MORE

  7. 5. Microglia in the juvenile brain after cranial irradiation

    Author : Kai Zhou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Radiotherapy is used to treat pediatric brain tumors and is often accompanied with debilitating late effects, such as cognitive decline. However, the mechanisms are poorly understood, and consequently there is still no effective treatment. READ MORE