Search for dissertations about: "CYP2R1"

Found 3 swedish dissertations containing the word CYP2R1.

  2. 1. Regulation of Vitamin D 25-hydroxylases : Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D

    Author : Maria Ellfolk; Kjell Wikvall; Maria Norlin; Olavi Pelkonen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP2D25; vitamin D 25-hydroxylase; transcriptional regulation; vitamin D; CYP2R1; CYP2J2; CYP27A1; phenobarbital; efavirenz; fibroblast; LNCaP; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Abstract : A 700bp portion of the promoter of CYP2D25, the porcine microsomal vitamin D 25-hydroxylase was isolated and sequenced. The computer analysis of the sequence revealed the existence of a putative VDRE at 220 bp upstream of the transcription start site. READ MORE

  4. 2. Aspects of Vitamin D : Prevalence of deficiency and impact on musculoskeletal parameters

    Author : Anne Björk; Östen Ljunggren; Gunnar Johansson; Andreas Kindmark; Anna Spångeus; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vitamin D; CYP2R1; Vitamin D receptor Gene; Polymorphisms; Muscle Strength; Endokrinologi och Diabetologi; Endocrinology and Diabetology;

    Abstract : Vitamin D is central in calcium turnover, and adequate levels are important for skeletal health. It is not clear how large contributions from food and sunlight are in Swedish primary care patients, considering the low radiation of UVB in Sweden and fortification of some foods, and whether differences exist between patients of immigrant and Swedish origin. READ MORE

  5. 3. Genetic causes and underlying disease mechanisms in early-onset osteoporosis

    Author : Anders Kämpe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Adult-onset osteoporosis is a disorder that affects a significant proportion of the elderly population worldwide and entails a substantial disease burden for the affected individuals. Childhood-onset osteoporosis is a rare condition often associating with a severe bone disease and recurrent fractures already in early childhood. READ MORE