Search for dissertations about: "CYR61"

Found 5 swedish dissertations containing the word CYR61.

  2. 1. Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy

    Author : Tereza Planck; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; association study; Graves’ disease; Graves’ ophthalmopathy; immediate early genes; inflammation; adipogenesis; thyrostimulin; BTG2; CYR61; COX2; ZFP36; gene expression; SCD; SNP;

    Abstract : Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. READ MORE

  4. 2. Molecular Mechanisms of Graves' Ophthalmopathy. A focus on smoking and radioiodine

    Author : Bushra Shahida; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Graves’ disease. Graves’ ophthalmopathy; radioiodine; inflammation; adipogenesis; IL-1ß; IL-6; PTGS2 COX2; PGE2; CTLA-4; B lymphocytes; T lymphocytes; Simvastatin; Diclofenac; SNP; gene expression; IGF-1;

    Abstract : Graves’ disease (GD) is an autoimmune disease characterized by hyperthyroidism and is caused by an interplayof genetic and environmental factors. One-third of patients with GD develop Graves’ ophthalmopathy (GO). Keyprocesses in the pathogenesis of GO are inflammation and adipogenesis in orbital tissue. READ MORE

  5. 3. MicroRNA expression and function in virus-associated human cancers

    Author : Hong Jr Xie; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : microRNAs (miRNAs) are small non-coding RNAs that play important roles in gene regulation. It is now clear that miRNAs participate in tumor development and progression. READ MORE

  6. 4. Mass Spectrometry-Based Protein Biomarker Discovery in Pancreatic Cancer

    Author : Qimin Zhou; Lund Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic cancer; proteomics; mass spectrometry; biomarkers; diagnosis; prognosis; prediction; BASP1; WT1; YAP1; AGP1;

    Abstract : Background: Pancreatic cancer has the lowest survival rate among all the major cancer types. Although recent decades have seen advances in diagnostic imaging, surgical techniques, perioperative care and oncological treatment, this has not been translated into major improvements in clinical outcome. READ MORE

  7. 5. On the role of forebrain cholinergic innervation for phencyclidine-induced behaviors and gene expression patterns

    Author : Sophia Savage; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The basalo-cortical cholinergic innervation reaches neural targets in cortex cerebri where it modulates the incoming sensory information, regulating arousal, attention, vigilance, memory and cognition. Progressive de generation of the cholinergic neurons in the basal forebrain is considered a hallmark of Alzheimer ’s disease related to cognitive impairment in this condition. READ MORE