Search for dissertations about: "Camp"

Showing result 1 - 5 of 216 swedish dissertations containing the word Camp.

  1. 1. THE ROLE OF PHOSPHODIESTERASE 3B IN CAMP-MEDIATED REGULATION OF INSULIN SECRETION

    University dissertation from Medical Faculty, Lund University

    Author : Helena Jones; Lunds universitet.; Lund University.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; PDE3B; exocytosis; insulin; diabetes; Medicine human and vertebrates ; Medicin människa och djur ; diabetologi; sekretion; Endokrinologi; diabetology; Endocrinology; secreting systems;

    Abstract : Type 2 diabetes mellitus (T2DM) is characterized by various combinations of ?-cell failure and insulin resistance leading to hyperglycemia and glucose intolerance. In order to maintain glucose tolerance in the insulin resistance state, increased insulin secretion is a requirement and it is because of inadequate islet adaptation that glucose intolerance develops in T2DM. READ MORE

  2. 2. On the Generation of cAMP Oscillations and Regulation of the Ca2+ Store-operated Pathway in Pancreatic Islet α- and β-cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Geng Tian; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; oscillations; adrenaline; GLP-1; phosphodiesterase; palmitate; STIM1; Orai1; store-operated calcium entry; insulin secretion; glucagon secretion; β-cell; α-cell; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Insulin and glucagon are released in pulses from pancreatic β- and α-cells, respectively. Both cell types are electrically excitable, and elevation of the cytoplasmic Ca2+ concentration ([Ca2+]i) due to depolarization with voltage-dependent entry of the cation is the main trigger of hormone secretion. READ MORE

  3. 3. Oscillatory Signaling and Insulin Secretion from Single ß-cells

    University dissertation from Uppsala : A U U

    Author : Olof Idevall Hagren; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; Ca2 ; oscillations; beta-cell; insulin secretion; evanescent wave microscopy; PIP3; PKA; Epac; MEDICINE Morphology; cell biology; pathology Cell biology Medical cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : cAMP and Ca2+ are key regulators of exocytosis in many cells, including insulin-secreting pancreatic β-cells. Glucose-stimulated insulin secretion from β-cells is pulsatile and driven by oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), but little is known about the kinetics of cAMP signaling and the mechanisms of cAMP action. READ MORE

  4. 4. The Role of Phosphodiesterase 3B in the Regulation of Insulin Secretion

    University dissertation from Linda Härndahl, C11 BMC, SE-221 84 Lund

    Author : Linda Härndahl; Lunds universitet.; Lund University.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; secreting systems; Endocrinology; beta-cell; diabetes; islet; PDE3B; cAMP;

    Abstract : Popular Abstract in Swedish Denna avhandling är en s.k. sammanläggningsavhandling och innehåller tre delarbeten. Delarbete I är publicerat, delarbete II är under revision inför publikation och delarbete III är i manuskriptform. READ MORE

  5. 5. Cyclic nucleotide signalling systems in vascular smooth muscle cells and immune system cells with special reference to phosphodiesterases PDE3 and PDE4

    University dissertation from Department of Cell and Molecular Biology, Lund University

    Author : Dag Ekholm; Lunds universitet.; Lund University.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HTLV-I; multiple sclerosis; proliferation; phosphorylation; T-lymphocytes; vascular smooth muscle; cloning; protein kinase A; cGMP; cAMP; PDE4; Phosphodiesterase; PDE3; cilostamide; rolipram; Histology; cytochemistry; histochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur;

    Abstract : Popular Abstract in Swedish Bakgrund: Signalsystem Alla flercelliga organismer är beroende av informationsöverföring mellan celler. Det behövs signaler från andra celler för att reglera tillväxt, ämnesomsättning m. fl. funktioner i olika vävnader. READ MORE