Search for dissertations about: "Cdc42"

Showing result 1 - 5 of 53 swedish dissertations containing the word Cdc42.

  2. 1. Cellular and molecular roles for CDC42 in angiogenesis

    Author : Marco Castro; Christer Betsholtz; Bàrbara Laviña; Rui Benedito; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CDC42; angiogenesis; endothelial cell; vascular malformation; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : Angiogenesis is the physiological process by which new blood vessels grow and critically depends on the interplay between the major vascular units: endothelial cells, pericytes and smooth muscle cells. Dysfunction and mispatterning of blood vessels are associated with the progression of many vascular complications, and therefore, understanding the causes of vascular dysmorphia is a central question in vascular biology. READ MORE

  4. 2. Cdc42, orchestrator of vascular morphogenesis in the retina

    Author : Alberto Álvarez-Aznar; Konstantin Gängel; Christer Betsholtz; Taija Mäkinen; Ondine Cleaver; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cdc42; endothelial cell; pericyte; mural cell; angiogenesis; CreERT2; Medicinsk vetenskap; Medical Science;

    Abstract : Cdc42 is a small GTPase that controls many cellular functions related to cytoskeletal dynamics, such as migration, polarity, and proliferation. Despite what we know of Cdc42 in other cell types, not much research has been done on the vasculature. READ MORE

  5. 3. Rho-GTPases in Morphogenesis and Differentiation of the Developing Pancreas

    Author : Thomas Greiner; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin; diabetes; beta cell; cell adhesion; migration; delamination; morphogenesis; tubulogenesis; pancreas; Cdc42; Rho-GTPase; Rac1;

    Abstract : Branched tubular networks constitute the basic structure of many organs to increase surface area and to transport fluids and gases. Glandular organs such as the pancreas arise from multilayered epithelium, which undergoes de novo lumen formation and extensive remodeling and branching. READ MORE

  6. 4. Activation, adhesion and motility of B lymphocytes in health and disease

    Author : Natalija Gerasimcik; Eva Severinson; Victor Tybulewicz; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; B cells; activation; motility; IL-4; EBV; Dock10; Cdc42; Rac1 and Rac2; immunologi; Immunology;

    Abstract : B cells can be activated by T cell-dependent stimuli, such as CD40 ligation and cytokines, which induce extensive proliferation, class switch recombination and somatic hypermutation.Epstein-Barr virus (EBV) can also induce B cell activation by mimicking T cell help through its main oncoprotein, latent membrane protein 1 (LMP-1). READ MORE

  7. 5. Regulation of GRAF1 membrane sculpting function during cell movement

    Author : Monika K. Francis; Richard Lundmark; Pekka Lappalainen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocytosis; migration; polarisation; tension; CLIC GEEC; GRAF1; Rho GTPase; Cdc42; Rab8; medicinsk biokemi; Medical Biochemistry;

    Abstract : All eukaryotic cells rely on endocytic events to satisfy a constant need for nutrient and fluid uptake from their surroundings. Endocytosis-dependent turnover of cell surface constituents also serves to control signal transduction and establish morphological changes in response to extracellular stimuli. READ MORE