Search for dissertations about: "Cell Proliferation drug effects radiation effects"

Showing result 1 - 5 of 9 swedish dissertations containing the words Cell Proliferation drug effects radiation effects.

  2. 1. Colorectal cancer and radiation response : The role of EGFR, AKT and cancer stem cell markers

    Author : Sara Häggblad Sahlberg; Bo Stenerlöw; Bengt Glimelius; Marika Nestor; Torgny Stigbrand; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; colorectal cancer; radiation; AKT; EGFR; cancer stem cells; CD133; CD44; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology;

    Abstract : The primary treatment for colorectal cancer is surgery. Radiotherapy and chemotherapy, sometimes combined, are also frequently used to diminish recurrence risk. In response to radiation exposure, several cellular signaling cascades are activated to repair DNA breaks, prevent apoptosis and to keep the cells proliferating. READ MORE

  4. 2. Plasminogen : a pleiotropic inflammatory regulator in radiation-induced wound formation and wound repair

    Author : Mahsa Fallah; Tor Ny; Malgorzata Wilczynska; Robert Medcalf; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The plasminogen activator (PA) system plays important roles in many physiological and pathological processes, including inflammation and wound healing. Plasmin, the central component of the PA system, is a broad-spectrum serine protease that is derived from its inactive precursor form, plasminogen. READ MORE

  5. 3. p63 – from expression to function : studies of normal oral mucosa and squamous cell carcinoma of the head and neck

    Author : Niklas Thurfjell; Karin Nylander; Phillip Coates; Göran Roos; Luisa Guerrini; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; p63; SCCHN; p53; BRCA1; Pathology; Patologi;

    Abstract : The human p63 gene discovered in 1997 encodes a series of protein isoforms that differ in their N- and/or C-terminal sequences. These isoforms have widely differing properties in promoting or repressing p53-related functions such as growth arrest and apoptosis. READ MORE

  6. 4. Roles of Myc and Mad in cell cycle and apoptosis

    Author : Ami Albihn; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myc; Mad; cell cycle; apoptosis; differentiation; tumorigenesis; chemotherapy;

    Abstract : The Myc network proteins are key mediators in regulation of cell growth, differentiation and apoptosis. They are basic region hehx-loop-helix/leucine zipper (bHLH/Zip) transcription factors that require hetero-dimerization with Max for specific DNA binding Mad family members are expressed primarily in differentiated tissues where they recruit histone deacetylase complexes via the mSin3 interaction domain (SID) to repress transcription of target genes and prevent cell growth In contrast, members of the Myc family activate target gene transcription by recruitment of histone acetyltransferases to their transcriptional activation domain (TAD), inducing proliferation and S phase entry. READ MORE

  7. 5. Investigating the role of neural stem/progenitor regulators in the context of brain tumor development

    Author : Isabelle Leefa Chong San; Stamcellscentrum (SCC); []
    Keywords : neural stem progenitor cells; regulators; brain tumor; cell of origin; cancer mechanisms;

    Abstract : Adult neural stem/progenitor cells (NSPs) are multipotent and self-renew over an extensive period of time. Transformation events in such cells, such as genetic or epigenetic alterations can result in brain tumors. READ MORE