Search for dissertations about: "Cellular responses to the DNA damaging Cytolethal Distending Toxin"

Found 2 swedish dissertations containing the words Cellular responses to the DNA damaging Cytolethal Distending Toxin.

2. 1. Cellular responses to the DNA damaging cytolethal distending toxin

   Author : Lina Guerra; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Cytolethal distending toxin (CDT) is a genotoxin, which belongs to a group of bacterial protein toxins called cyclomodulins. These are characterized by their interference with the eukaryotic cell cycle. CDT causes DNA damage, which induces cell cycle arrest and apoptosis. READ MORE

4. 2. Bacteria and cancer : from toxin delivery to carcinogenesis

   Author : Riccardo Guidi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Epidemiological evidence link certain chronic bacterial infections to a higher risk of cancer development. Induction of an inflammatory circuit and the accumulation of genomic instability are considered mechanisms by which bacteria contribute to malignant transformation. READ MORE